Autonomic Nervous System Clinical Trial
Official title:
Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Following deployment to Operations Enduring and Iraqi Freedom and Operation New Dawn (OEF/OIF/OND), Veterans report breathing problems, difficulty exercising and other symptoms. These symptoms may be related to deployment exposures, such as regional dust and sand, smoke from burning trash, and local industry. Studies have reported poor air quality, but very little is known about the effect that exposure to this polluted air may have on Veterans' short- and long-term health. Investigators will determine whether deployment-related exposures have affected respiratory and nervous system function in these Veterans - data that may then be used to guide rehabilitation. Ultimately, the investigators' long-term goal is to prevent the development of chronic respiratory conditions in this group of OEF/OIF/OND Veterans.
Evidence is clear that Veterans deployed to Operations Enduring and Iraqi Freedom and
Operation New Dawn (OEF/OIF/OND) have been exposed to high levels of particulate matter (PM)
that exceeded environmental, occupational and military exposure guidelines. PM exposure is
acknowledged as a risk factor for cardiovascular morbidity and mortality, and can increase
the risk of and exacerbate airway disease. The reviewed epidemiology indicates a high
prevalence of newly reported respiratory symptoms in OEF/OIF/OND Veterans that has
significantly affected their deployment duties, including their physical exertion
capability. Despite these retrospective data and limited air sampling reports, prospective
studies are lacking. This pilot study will evaluate cardiorespiratory and autonomic function
in OEF/OIF/OND Veterans as compared to Veterans never deployed to the region.
To evaluate cardiopulmonary function, each Veteran will undergo a standardized exercise
challenge and bronchodilator spirometry. To evaluate autonomic nervous system function,
investigators will examine indices of heart rate variability and cardiovascular reflex
regulation (e.g. baroreflex sensitivity and cerebral autoregulation) during a variety of
tasks.
Data derived from this pilot project will yield important insight on the extent and severity
of cardiorespiratory and/or autonomic impairments - data that may provide intervention
points for attenuating long-term adverse outcomes such as pulmonary and cardiovascular
disease. Through early identification, treatment options (e.g. exercise therapy,
pharmaceutical) may be implemented to enhance physiological function, with the goal of
helping to alleviate symptoms and reduce chronic disease risk.
;
Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03566186 -
Effects of Phototherapy Associated With Sprint and Squat Training on Cardiac Autonomic Modulation
|
N/A | |
| Completed |
NCT01574196 -
Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood
|
N/A | |
| Completed |
NCT04476368 -
Effect of Yoga in Pregnancy on Cardio-respiratory Adaptation to Challenge
|
N/A | |
| Completed |
NCT04579497 -
Temperature-dependent Changes in Cardiovascular Parameters During Warm Water Footbaths in Healthy Women
|
N/A | |
| Not yet recruiting |
NCT05099354 -
The Effect of Endovascular Thrombectomy on Autonomic Nervous System in Patients With Large-vessel Ischemic Stroke
|
||
| Completed |
NCT02469844 -
Heart Rate Variability (HRV) Analysis in Patients With Nocturnal Epileptic Seizures
|
||
| Recruiting |
NCT05454735 -
Glycemic Variability and Autonomic Nervous System in Cardiac Surgery Patients
|
||
| Completed |
NCT04487899 -
Analysis of Heart Rate Variability During Emergency Flight Simulator Missions in Fighter Pilots
|
||
| Completed |
NCT05084313 -
Acute Effects of Deep-Slow Breathing Exercise and Cranial-Visceral Manual Therapy on ANS Parameters in Healthy Adults
|
N/A | |
| Completed |
NCT04896424 -
Vagal Response and Cardiac Autonomic Modulation. Insides From Cryoballoon Ablation
|
N/A | |
| Recruiting |
NCT05706532 -
Cardiovascular and Cerebrovascular Control in Healthy Subjects
|
||
| Not yet recruiting |
NCT06381089 -
Effect Of Robotic Rehabilitation And Vagus Nerve Stimulation In Ischemia Stroke Patients
|
N/A | |
| Not yet recruiting |
NCT06288828 -
The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis
|
N/A | |
| Recruiting |
NCT05807555 -
Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children
|
||
| Completed |
NCT05289817 -
Effects of Transcutaneous Electrical Stimulation on the Autonomous Nerve System in Healthy Young People
|
N/A | |
| Completed |
NCT03200483 -
Musical Auditory Stimulation and Exercise
|
N/A | |
| Recruiting |
NCT06259201 -
Vagus Nerve Stimulator for Autism and Other Developmental Disorders
|
N/A | |
| Completed |
NCT01185457 -
Effect of Interscalene Block on Heart Rate Variability (HRV)
|
N/A | |
| Recruiting |
NCT04057508 -
Non-invasive Modulation of Autonomic Cardiac Nervous System
|
N/A | |
| Completed |
NCT03232879 -
Combining Motor Imagery With Action Observation Does Not Lead to a Greater Autonomic Response Than Motor Imagery Alone During Simple and Functional Movements: a Randomized Controlled Trial.
|
N/A |