Clinical Trials Logo
  1. Home
  2. Autoimmune Hemolytic Anemia
  3. NCT06231368

CNCT19 for Patients With Autoimmune Hemolytic Anemia After Failure ≥3 Lines of Therapy.

Autoimmune Hemolytic Anemia Clinical Trial

Official title:
The Safety and Efficacy of CNCT19 for Patients With Autoimmune Hemolytic Anemia After Failure of Three or More Lines of Therapy

Clinical Trial Summary

This is a Phase 1, single-arm, open-label, dose-escalation and dose-expansion study. The main purpose is to evaluate the safety and tolerability, efficacy of CNCT19 CAR T-cell therapy in patients with autoimmune hemolytic anemia after failure of three or more lines of therapy. Participants will receive CNCT19 cell infusion after preconditioning, and they will receive a 1-year follow-up.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06231368
Study type Interventional
Source Institute of Hematology & Blood Diseases Hospital, China
Contact Jun Shi, PhD
Phone 13752253515
Email shijun@ihcams.ac.cn
Status Recruiting
Phase Phase 1
Start date February 4, 2024
Completion date August 31, 2025
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05057481 - Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus Phase 3
Recruiting NCT05937828 - OBS'CEREVANCE: French Cohort of Pediatric Autoimmune Cytopenia
Recruiting NCT05263817 - A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis Early Phase 1
Completed NCT03269292 - Clinical Characteristics and Treatment Outcomes of Patients With Autoimmune Hemolytic Anemia
Recruiting NCT05694312 - Ibrutinib for the Treatment of AIHA in Patients With CLL/SLL or CLL-like MBL Phase 2
Completed NCT03538041 - A Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia Phase 2
Recruiting NCT03918265 - Tacrolimus Treatment for Refractory Autoimmune Cytopenia Phase 4
Completed NCT02389231 - Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Phase 1/Phase 2
Active, not recruiting NCT03576742 - Severe Immune Cytopenia Registry Www.Sic-reg.Org
Active, not recruiting NCT04657094 - Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia Phase 2
Recruiting NCT02828670 - Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA)
Recruiting NCT02877706 - French Registry of Adult Patients With Immune Thrombocytopenia and Autoimmune Hemolytic Anemia
Recruiting NCT05931718 - Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia
Completed NCT02158195 - Immunopathology of Autoimmune Hemolytic Anemia
Completed NCT00001630 - Treatment of Autoimmune Thrombocytopenia (AITP) Phase 1
Withdrawn NCT04039477 - A Phase 2 Study to Evaluate the Safety and Efficacy of KZR-616 in Patients With AIHA and ITP Phase 2
Recruiting NCT04024202 - Data Registry of Auto Immune Hemolytic Anemia
Not yet recruiting NCT05711264 - Presence of Circulating Cluster of Differentiation 4 Positive 28 Null T Helper Lymphocytes(CD4+CD28-) in Patients With Autoimmune Hemolytic Anemia.
Completed NCT02689986 - Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Phase 2
Recruiting NCT06212154 - CAR-T for Autoimmune Hemolytic Anemia Patients Who Have Failed Three or More Lines of Therapy Phase 1