Clinical Trials Logo

Clinical Trial Summary

1. Study the presence of circulating CD4+/CD28 null T lymphocytes in AIHA either Idiopathic or Secondary. 2. Role of CD4+/CD28 null T lymphocytes in monitoring response to therapy in AIHA.


Clinical Trial Description

Autoimmune hemolytic anemia (AIHA) has always been considered the simplest and most scholastic example of antibody-mediated autoimmune disease.It has been identified as a greatly heterogeneous disease, due to several immunological mechanisms involved beyond antibodies, complement and antibody-dependent cell-mediated cytotoxicity (ADCC). AIHAs may be Idiopathic of unknown cause Secondary associated with several conditions : (lymphoproliferative, autoimmune , infectious diseases, immunodeficiencies, solid tumors, transplants, and drugs).Several subsets of T and B lymphocytes with highly specialized functions have been characterized. Some lymphocytes promote inflammation, while others have anti-inflammatory roles, and an optimal balance between these two opposing sets of lymphocytes is critical for immune homeostasis. A pro-inflammatory subset of CD4+ T helper 1 (Th1) lymphocytes known as cluster of differentiation 4 positive 28 negative T helper lymphocytes (CD4+CD28 null T cells) because they characteristically lack CD28 which is a co-stimulatory receptor critical for the activation and function of T cells.CD4+CD28 null T cells are rare in healthy individuals, but they increase in inflammatory and immune-mediated diseases. Prevalence of CD4+CD28 null T cells is high in chronic inflammatory diseases, autoimmune diseases, immunodeficiency and specific infectious diseases.It remains controversial whether CD4+CD28null T cells are antigen specific and which are the precise antigens that trigger their expansion. It has been suggested that CD4+CD28null T lymphocytes are auto-reactive and that repeated stimulation by auto-antigens drives the expansion of this cell subset.Expansion of the CD4+CD28 null T-cell subset in patients affected by autoimmune disorders has been linked to the severity of disease and an unfavourable prognosis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05711264
Study type Observational
Source Assiut University
Contact Amira ehab
Phone 01005305860
Email amira.ehab99@yahoo.com
Status Not yet recruiting
Phase
Start date January 30, 2023
Completion date April 1, 2025

See also
  Status Clinical Trial Phase
Active, not recruiting NCT05057481 - Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematosus Phase 3
Recruiting NCT05937828 - OBS'CEREVANCE: French Cohort of Pediatric Autoimmune Cytopenia
Recruiting NCT05263817 - A Clinical Study of CD19/BCMA CAR-T Cells in the Treatment of Refractory POEMS Syndrome, Amyloidosis, Autoimmune Hemolytic Anemia, and Vasculitis Early Phase 1
Completed NCT03269292 - Clinical Characteristics and Treatment Outcomes of Patients With Autoimmune Hemolytic Anemia
Recruiting NCT05694312 - Ibrutinib for the Treatment of AIHA in Patients With CLL/SLL or CLL-like MBL Phase 2
Completed NCT03538041 - A Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia Phase 2
Recruiting NCT03918265 - Tacrolimus Treatment for Refractory Autoimmune Cytopenia Phase 4
Completed NCT02389231 - Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Phase 1/Phase 2
Active, not recruiting NCT03576742 - Severe Immune Cytopenia Registry Www.Sic-reg.Org
Active, not recruiting NCT04657094 - Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia Phase 2
Recruiting NCT02828670 - Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA)
Recruiting NCT02877706 - French Registry of Adult Patients With Immune Thrombocytopenia and Autoimmune Hemolytic Anemia
Recruiting NCT05931718 - Prospective Evaluation of Diagnosis and Treatment of Patients With Autoimmune Cytopenias Including Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, and Chronic Idiopathic/Autoimmune Neutropenia
Completed NCT02158195 - Immunopathology of Autoimmune Hemolytic Anemia
Completed NCT00001630 - Treatment of Autoimmune Thrombocytopenia (AITP) Phase 1
Withdrawn NCT04039477 - A Phase 2 Study to Evaluate the Safety and Efficacy of KZR-616 in Patients With AIHA and ITP Phase 2
Recruiting NCT04024202 - Data Registry of Auto Immune Hemolytic Anemia
Completed NCT02689986 - Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Phase 2
Recruiting NCT06212154 - CAR-T for Autoimmune Hemolytic Anemia Patients Who Have Failed Three or More Lines of Therapy Phase 1
Completed NCT04057703 - Balance Benefit / Risk of Immunomodulatory Treatments at the Child and Adolescent for Autoimmune Cytopenia.