Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

Autoimmune Diseases Clinical Trial

— Etude thyrovir  

Official title:

Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03114267
• Other study ID #: PI11-PR-DESAILLOUD-1
• Status: Completed
• Phase: N/A
• First received: April 11, 2017
• Last updated: April 11, 2017
• Start date: January 6, 2012
• Est. completion date: January 6, 2015

Study information

• Verified date: April 2017
• Source: Centre Hospitalier Universitaire, Amiens
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.

Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.

It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 64
• Est. completion date: January 6, 2015
• Est. primary completion date: January 6, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients participating in PHRC 2005 "involvement of enteroviruses in TLC pathogenesis"

• Inclusion of TLC: presence of a significant lymphocyte infiltrate within the thyroid parenchyma defined by the presence of clusters of more than 30 to 50 lymphocytes

• Inclusion of controls: absence of significant lymphocyte infiltrate

Exclusion Criteria:

• Persons refusing to participate in research

Related Conditions & MeSH terms

• Autoimmune Diseases
• Chronic Lymphocytic Thyroiditis
• Hashimoto Disease
• Thyroiditis
• Thyroiditis, Autoimmune
• Virus Diseases

Intervention

Other:
• Comparison of the prevalences of the parvovirus genome
Comparison of the prevalences of the parvovirus genome between cases and controls and then of other viruses according to the results of parvoviruses and data from the literature

Locations

Country	Name	City	State
France	CHU Amiens Picardie	Amiens	Picardie

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire, Amiens

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Analysis of the viral genome by PCR carried out in the Virology department, Analysis of the presence of capsid protein		1 day