Autoimmune Diseases Clinical Trial
Official title:
Experimental Autologous Mesenchymal Stem Cell Therapy in Treatment of Chronic Autoimmune Urticaria
The aim of this study is to determine whether autologous adipose tissue derived Mesenchymal Stem Cells of treatment for chronic autoimmune urticaria is safe and effective.
Chronic urticaria is a distressful disease, which negatively affects the quality of life.
Pathogenesis isn't exactly clear, treatment is relatively palliative and results are usually
suboptimal. 30-40% of the patients have autoimmune origin. Patients are forced to use
immunosuppressive treatments which have systemic effects. Some of the treatments have effects
as severe as the disease itself.
Mesenchymal stem cells (MSCs) are the most common used cells in clinical trials. These cells
can provide efficient immunosuppression in severe conditions like immunosuppressive resistant
Graft versus Host Disease. With this study at the first time and quite a different approach
from conventional treatment, it will be tried an experimental treatment that used in the MSCs
for the chronic autoimmune urticaria patients without of definitive treatment.
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