Autoimmune Diseases Clinical Trial
OBJECTIVES:
I. Determine the response rate and 1-year event-free survival in patients with severe
autoimmune hematologic disease treated with high-dose cyclophosphamide.
PROTOCOL OUTLINE: Patients receive high-dose cyclophosphamide IV on days 1-4 and filgrastim
(G-CSF) starting on day 10 and continuing until blood counts recover.
Patients are followed at 1, 3, 6, and 12 months and then annually thereafter.
;
Intervention Model: Single Group Assignment, Primary Purpose: Treatment
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