Autoimmune Disease Clinical Trial
Official title:
Evaluation of 18F-FDG PET/CT in Diagnosis and Response Assessment of Patients With IgG4-Related Disease
This is an open-label study to investigate the diagnostic performance of 18F-FDG PET/CT (positron emission tomography/computed tomography) in evaluation of patients with IgG4-related disease. A single dose of 18F-FDG will be intravenously injected into patients with IgG4-related disease before and after treatment.
Immunoglobulin G4-related disease (IgG4-RD) is a recently defined emerging clinical entity
characterized by tissue infiltration by IgG4-positive plasma cells, tissue fibrosclerosis
and elevated serum IgG4 concentration. The most important feature of IgG4-RD is chronic
inflammation with multiple organ involvement. However, some organ involvements are difficult
to find by ultrasound, CT or MRI.
18F-FDG PET/CT is a sensitive imaging tool for inflammation. In this study, PET/CT were
performed in patients with IgG4-RD both before and after glucocorticoid treatment by a
single dose of 18F-FDG. Visual and semiquantitative method will be employed to assess the
PET/CT images. The PET/CT image data will be used to establish a diagnostic model as well as
assessment criteria for response evaluation of IgG4-RD treatments.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT01934764 -
Identification of Correlations Between Reaction to Biotine and Autoimmune Diseases
|
N/A | |
| Withdrawn |
NCT02948855 -
Regulation of LncRNA For Breg in Patients With Thymoma and Autoimmune Diseases
|
||
| Completed |
NCT01815996 -
Identify Clinical Conditions That Increase Circulating DNA Levels
|
||
| Completed |
NCT02434458 -
Sudoscan in Patients With Autoimmune Disorders
|
N/A | |
| Completed |
NCT02263703 -
Immunogenicity of HPV Vaccine in Immunosuppressed Children
|
Phase 3 | |
| Completed |
NCT00013689 -
Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative Syndrome
|
Phase 1 | |
| Completed |
NCT00340600 -
Continuation of Follow-up of DES-Exposed Cohorts
|
||
| Not yet recruiting |
NCT05894707 -
Evaluate the Safety and Tolerability of SCT650C in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT02647866 -
Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis
|
Phase 2 | |
| Active, not recruiting |
NCT00716066 -
Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases
|
Phase 2 | |
| Completed |
NCT00351377 -
Gastrointestinal and Health-related Quality of Life Outcomes in Patients With Autoimmune Diseases Treated With Mycophenolate
|
Phase 3 | |
| Completed |
NCT00114530 -
Scleroderma: Cyclophosphamide or Transplantation
|
Phase 2/Phase 3 | |
| Completed |
NCT00001630 -
Treatment of Autoimmune Thrombocytopenia (AITP)
|
Phase 1 | |
| Completed |
NCT00372177 -
The Use of Anti-CD4 Monoclonal Antibody (mAb)-Fragment for the Imaging of Chronic Inflammation in Patients With Active Rheumatoid Arthritis
|
Phase 1/Phase 2 | |
| Completed |
NCT00065390 -
Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome
|
Phase 1 | |
| Completed |
NCT00001658 -
Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections
|
Phase 4 | |
| Recruiting |
NCT03816345 -
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
|
Phase 1 | |
| Completed |
NCT00001306 -
Steroid Therapy in Autoimmune Premature Ovarian Failure
|
N/A | |
| Recruiting |
NCT03715699 -
Leflunomide Treatment for IgG4-RD
|
N/A | |
| Completed |
NCT02925351 -
Fluorine F 18 Clofarabine PET/CT in Imaging Patients With Autoimmune or Inflammatory Diseases
|
Early Phase 1 |