Autistic Disorder Clinical Trial
Official title:
Citalopram Treatment in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior
This study will determine the efficacy and safety of citalopram compared to placebo in the treatment of children with autism.
For children with autism spectrum disorders (ASD, also known as Pervasive Developmental
Disorders - PDDs), repetitive behaviors are common and frequently interfere with functioning
in the home as well as in social and educational settings. These behaviors may involve
repetitive movements, rigid routines, repetitive play, and even repetitive speech. These
behaviors may be associated with high levels of anxiety, severe tantrums. Self-injury can
occur when these behaviors and routines are interrupted.
Participants will be randomly assigned to receive citalopram or placebo (administered as
liquid), and carefully followed every two weeks. At the end of 12 weeks, children who have
responded to treatment will be given the opportunity to continue in the study, with monthly
visits, for an additional 24 weeks. Children who received placebo and did not respond to
treatment at 12 weeks will be given the opportunity to receive a carefully monitored 12 week
course of citalopram.
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