Multisensorial Information's Treatment in Autism Spectrum Disorder

Autism Clinical Trial

Official title:

Exploring Social Cognition in Autism Spectrum Disorder With Long Time Memory Task. Controlled Study on 8-13 Years Childs

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02579109
• Other study ID #: 13AOI09
• Status: Completed
• Phase: N/A
• First received: September 29, 2015
• Last updated: October 16, 2015
• Start date: February 2014
• Est. completion date: August 2014

Study information

• Verified date: October 2015
• Source: Centre Hospitalier Universitaire de Nice
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé
• Study type: Interventional

Clinical Trial Summary

Introduction:

Autism spectrum disorder is characterized by deficits in three functional domains: language and communication, social reciprocity, and the presence of restricted interests/repetitive behaviors. There's also deficits in social cognition. When having a face-to-face conversation, a listener not only hears what a speaker is saying, but also sees the articulatory gestures that accompany those sounds. Speech signals needs then a multisensory processing. Impairments in multisensory perceptual binding may be particularly relevant in ASD, given that hallmark features of the disorder include difficulties in speech, communication, and social interactions.

Objectives:

The investigator suggest that atypical multisensory processing in ASD may have an impact on speech perception and social processing.

Aims:

Methods:

This pilot study measures free recall scores in 3 lists of words presentation after 30 minutes. In the first condition (CI) words are only listening. In the second condition (CII) words are associated with a picture of a mans face. In the third condition (CIII) words are associated with a video of a man speaking. Three lists are homogeneous form words characteristics (lexical frequency, emotional valence norm, imageability). Participants were 7- to 13-year-olds typically developing children (TD) (N = 19) and ASD children (N = 19).

The investigator would create some new tools for exploring the treatment of a social information. These tools should be the closest of a ecological social interaction.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 38
• Est. completion date: August 2014
• Est. primary completion date: February 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 7 Years to 13 Years

Eligibility

Inclusion Criteria:

• Boy or girl,

• 7 - 13 years,

• Presenting a diagnosis DSM IV of disorder(confusion) of the autistic spectre:

detected by the scale(ladder) ADI ( Autism Diagnostic Interview) or by TEENAGERS (Autism Diagnostic Observation Schedule): typical autistic. These patients do not answer the diagnosis of psychosis according to Kiddie-SADS,

• Upper total IQ or equal to 50, examination dating less than year before the inclusion,

• French-speaking children,

• Signature of the informed consent by the parents(relatives) and the child,

• Membership to the Social Security.

Exclusion Criteria:

• Genetic, neurological or neurosensory pathologies,

• Diagnosis of intrusive disorder(confusion) of the not specified development: TED our,

• The patients will not be included who would participate in a program or a study of reeducation in the social fitnesses.

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Autism
• Autistic Disorder
• Child Development Disorders, Pervasive

Intervention

Other:
• memory test

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nice

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	rate of reminder after 30 minutes between the group autistic and the group witness( %)	Comparison between the group autistic and the group witness of the difference enter the rate of reminder(abseiling) in 30 minutes of the words proposed in video and audio sequences.	30 minutes	No
Secondary	Difference of the scores of reminders words (%)	Difference of the scores of reminders between the both group, immediately after procedure and 30 minutes after procedure	30 minutes	No