rTMS for Adults With Autistic Spectrum Disorder

Autism Clinical Trial

Official title:

Examine the Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Symptoms of Autism Spectrum Disorder

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01918787
• Other study ID #: 100-2985C
• Secondary ID: NSC 100-2314-B-1
• Status: Recruiting
• Phase: Phase 1/Phase 2
• First received: August 2, 2013
• Last updated: August 7, 2013
• Start date: April 2012
• Est. completion date: April 2015

Study information

• Verified date: April 2012
• Source: Chang Gung Memorial Hospital
• Contact: Hsing Chang Ni, MD
• Phone: 886-3-3281200
• Email: alanni0918[@]yahoo.com.tw
• Is FDA regulated: No
• Health authority: Taiwan: Department of Health
• Study type: Interventional

Clinical Trial Summary

rTMS over dorsolateral prefrontal cortex is effective in reducing repetitive behaviors in adults with autistic spectrum disorder rTMS over posterior superior temporal sulcus is effective in improving social ability in adults with autistic spectrum disorder

Description:

First, we will apply one session intermittent theta burst stimulation over dorsolateral prefrontal cortex, posterior superior temporal sulcus and inion as control with one week interval in adults with autism spectrum disorder. Second, we will apply 5 sessions intermittent theta burst stimulation within one week over dorsolateral prefrontal cortex or posterior temporal sulcus depending on the results of our first phases.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: April 2015
• Est. primary completion date: April 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• adults with autistic spectrum disorder

Exclusion Criteria:

• schizophrenia

• bipolar affective disorder

• major depressive disorder

• any systemic disease especially epilepsy

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Autism

Intervention

Device:
• repetitive TMS
rTMS (intermittent theta burst stimulation 1200)over posterior superior temporal sulcus,dorsolateral prefrontal cortex and inion as Sham control

Locations

Country	Name	City	State
Taiwan	Chang Gung Memorial Hospital	Taoyuan

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Autism Spectrum Quotient	Autism Spectrum Quotient will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS.	Autism Spectrum Quotient will be evaluated before and after rTMS within one week	No
Primary	continuous performance test	continuous performance test will be arranged before and after rTMS within one hour	continuous performance test will be arranged before and after rTMS within one hour	No
Secondary	Yale-Brown Obsessive Compulsive Scale	Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS.	Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS within one week	No