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NCT00463164 Clinical Trial

Functional MRI of Cognitive Control in Autism

Autism Clinical Trial

Official title:
Functional MRI of Cognitive Control in Autism

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT00463164
Other study ID # 06-179
Secondary ID
Status Not yet recruiting
Phase N/A
First received April 19, 2007
Last updated April 19, 2007
Start date December 2007

Study information
Verified date April 2007
Source UMC Utrecht
Contact Sarah Durston, Ph.D.
Phone +31 30 250 8161
Email S.Durston@umcutrecht.nl
Is FDA regulated No
Health authority Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Study type Observational

Clinical Trial Summary

This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 90
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 6 Years to 12 Years
Eligibility Inclusion Criteria:

- Aged 6 - 12 years at inclusion

Inclusion criteria for subjects with autism

- DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview

Inclusion criteria for controls

- No DSM-IV (APA, 1994) diagnosis, according to DISC interview

- No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)

- IQ > 70

Exclusion Criteria:

- Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system

- Presence of metal objects in or around the body (pacemaker, dental braces)

- History of or present neurological disorder

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Netherlands Dept. of Child and Adolescent Psychiatry, UMC Utrecht Utrecht

Sponsors (1)
Lead Sponsor Collaborator
UMC Utrecht

Country where clinical trial is conducted

Netherlands, 

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