Autism Clinical Trial
Official title:
Magnetic Resonance Imaging in Children and Adolescents With Autism and Multiple Complex Developmental Disorders
NCT number | NCT00161135 |
Other study ID # | WOM 98/261 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | September 8, 2005 |
Last updated | April 19, 2007 |
Start date | January 1999 |
This study aims to investigate the overlap and differences between autism and MCDD as neuropsychiatric childhood disorders. MRI scans are acquired from subjects with autism, subjects with a diagnosis of MCDD and typically developing controls. Volumetric measure of various brain regions are compared between groups. We hypothesize that subjects with autism will have larger brains than controls, whereas subjects with MCDD will have smaller brains.
Status | Completed |
Enrollment | 150 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 7 Years to 24 Years |
Eligibility |
Inclusion Criteria: - Diagnosis of autism according to ADI-interview or diagnosis of MCDD according to the MCDD-checklist or no psychiatric diagnosis (controls) Exclusion Criteria: - Some medical and neurological diseases (if there are influences on the brain structures) - Alcohol or drug abuse - IQ < 70 - Focal abnormalities on the MRI scan |
Observational Model: Case Control, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
Netherlands | Dept. of Child and Adolescent Psychiatry, UMC Utrecht | Utrecht |
Lead Sponsor | Collaborator |
---|---|
UMC Utrecht |
Netherlands,
Palmen SJ, Hulshoff Pol HE, Kemner C, Schnack HG, Durston S, Lahuis BE, Kahn RS, Van Engeland H. Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorder. Psychol Med. 2005 Apr;35(4):561-70. — View Citation
Palmen SJ, Hulshoff Pol HE, Kemner C, Schnack HG, Janssen J, Kahn RS, van Engeland H. Larger brains in medication naive high-functioning subjects with pervasive developmental disorder. J Autism Dev Disord. 2004 Dec;34(6):603-13. — View Citation
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