Unexpected ABR Results in Patients Suspected With Auditory Neuropathy Spectrum Disorder

Auditory Neuropathy Clinical Trial

Official title:

Unexpected ABR Results in Patients Suspected With Auditory Neuropathy Spectrum Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06125015
• Other study ID #: E-10840098-772.02-3627
• Status: Completed
• Phase: N/A
• Start date: January 20, 2015
• Est. completion date: November 30, 2021

Study information

• Verified date: November 2023
• Source: Istanbul Medipol University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aimed to assess the clinical evaluations and potential underlying pathologies in patients diagnosed with Auditory Neuropathy Spectrum Disorder (ANSD) who exhibited unusual results in audiological tests. The research involved the retrospective analysis of audiological tests of 11 patients conducted by expert audiologists at Istanbul Medipol Mega Hospital between 2010 and 2020. These patients displayed abnormalities in their Auditory Brainstem Response (ABR) tests. The study sought to investigate patients with ANSD who presented atypical audiological findings, shedding light on the associated clinical aspects and potential causes of such anomalies.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: November 30, 2021
• Est. primary completion date: November 30, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 0 Years to 46 Years

Eligibility

Inclusion Criteria:

• Presence of wave V with cochlear microphonics

Exclusion Criteria:

• Type B tympanogram

Related Conditions & MeSH terms

• Auditory Neuropathy
• Hearing Loss, Central

Intervention

Diagnostic Test:
• Hearing Thresholds Assessments
Auditory Neuropathy Spectrum Disorder (ANSD) is a type of hearing disorder that affects the transmission of sound signals from the inner ear to the brain. In individuals with ANSD, the outer hair cells in the cochlea, which are responsible for amplifying sound, typically function properly. However, there is a disruption in the transmission of auditory information from the cochlea to the auditory nerve and then to the brain. It is characterized by a mismatch between the results of objective hearing tests, such as Auditory Brainstem Response (ABR), and subjective hearing experiences. In ABR tests, the responses of the auditory nerve to sounds may be abnormal, while the individual perceives their hearing to be better than suggested by the test results. In this study we showed ANSD patients with abnormal ABR results by using ABR, Otoacoustic Emissions, Tympanometry and behavioral test batteries.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Istanbul Medipol University Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measuring Hearing Thresholds with Electrophysiological Tests	Participants' hearing thresholds and cochlear microphonics evaluated by using Auditory Brainstem Responses and Otoacoustic Emissions.	6 years
Primary	Evaluating Middle Ear Pathologies	Participants' middle ear pathologies evaluated by using Tympanometry	6 years
Primary	Evaluating Hearing Thresholds by Using Behavioral Tests	Participants' reactions to sounds were assessed using Free Field Audiometry or headphones. These evaluations were conducted initially at the time of diagnosis and subsequently after the patients had started using hearing aids.	6 years