Schizophrenia Clinical Trial
Official title:
Anodal & Cathodal tDCS for Treatment of Resistant Auditory Hallucinations in Schizophrenia
The purpose of this study is to determine whether trans Direct Current Stimulation (tDCS) is effective in the treatment of auditory hallucinations in schizophrenia.
The project will investigate the use of a novel technique, transcranial direct current
stimulation (tDCS) in the treatment of patients with schizophrenia. tDCS permit the
application of an extremely weak continuous electrical current to the brain through an anode
and a cathode applied on the scalp. Anodal stimulation appears to increase brain activity
whereas cathodal stimulation has the opposite effect.
Using anodal & cathodal tDCS the investigators aimed to treat auditory hallucinations, a
symptoms of schizophrenia. The investigators plan to apply tDCS such that it can
simultaneously increased activity in the frontal brain areas and reduce activity over
temporoparietal cortex, 2 areas involved in the physiopathology of the disease. Real active
stimulation will be compare to a sham condition in 60 patients (30 in each group). 30
patients will be included in a French center (Hospital le Vinatier, sponsor of the study)
and 30 in Tunisia (laboratory "vulnerability to psychosis" (Pr Gaha) à Monastir).
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