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AMX0035 and Progressive Supranuclear Palsy — ORION  

Neurodegenerative Diseases Clinical Trial

Official title:
A Phase 3 Study of Safety and Efficacy of AMX0035 in Progressive Supranuclear Palsy (ORION)

Clinical Trial Summary

ORION Trial is a trial to evaluate the efficacy and safety of AMX0035 in participants with Progressive Supranuclear Palsy (PSP), consisting of a randomized double blind placebo controlled phase, followed by an optional open-label extension phase.

Clinical Trial Description

AMX0035 is a combination therapy designed to reduce neuronal death through blockade of key cellular death pathways originating in the endoplasmic reticulum (ER) and mitochondria. This clinical trial is designed to demonstrate that AMX0035 is safe and tolerable, and to assess its effect on disease progression as measured by the Progressive Supranuclear Palsy (PSP) Rating Scale (PSPRS) over a 52-week double-blind phase. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06122662
Study type Interventional
Source Amylyx Pharmaceuticals Inc.
Contact The Harte Group
Phone +44 (808) 1642604
Email clinicaltrials@amylyx.com
Status Recruiting
Phase Phase 3
Start date December 21, 2023
Completion date May 31, 2027
View Details
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