Attention Deficit Clinical Trial
— INHIB'MOVOfficial title:
Assessment of Brain Activity Associated With Inhibition of Action in Attention-deficit Hyperactivity Disorder
Inhibitory control allows individuals to suppress unwanted actions and to resist irrelevant stimuli. It is thought to be a core deficit in Attention-deficit/hyperactivity disorder (ADHD). The present study aims at evaluating this deficit in adults with ADHD. Executive and inhibitory capacities, as well as the neural mechanisms underlying inhibitory control, will be assessed in adults with ADHD and two control groups of participants.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | December 2024 |
Est. primary completion date | December 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Age between 18 and 50, - Visual, auditory (authorized apparatus), motor skills suitable for the proper realization of neuropsychological tests, - Being right-handed, - Free, informed and written consent signed by the participant and the investigator - Person affiliated or beneficiary of a social security scheme. - For the ADHD group: - Diagnosis of ADHD according to DSM-V criteria (APA, 2013), For the patient control group: • Patient who consulted for a cognitive complaint and for whom the diagnosis of ADHD was rejected according to the criteria of DSM-V (APA, 2013). Exclusion Criteria: - General or progressive neurological disease resulting in cognitive impairment (multiple sclerosis, Parkinson's disease, stroke, etc.), - Insufficient linguistic level in French to participate in neuropsychological assessment, - Patient placed under judicial protection or under another protective regime, - Severe depression according to DSM-V criteria (APA, 2013), - Autism spectrum disorder, developmental coordination disorder. -For the healthy voluntary control group: - Presence of a cognitive complaint or pathology which may impair his cognitive functions |
Country | Name | City | State |
---|---|---|---|
France | Toulouse Purpan University Hospital | Toulouse |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Toulouse | Centre National de la Recherche Scientifique, France |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | EEG correlates of inhibition | The main objective of this study is to evaluate, by electrophysiological measures, the presence of a deficit of action inhibition in adults with ADHD. To this end, the EEG correlates of inhibition will be compared between participants in the three groups. Thus, the ERP (N2 / P3) and ERSP (Theta, Delta) variations observed in terms of amplitude and latency in the stop-signal task tests will be computed in each of the three groups. | 2 weeks | |
Secondary | Inhibition performance from a rhythmic-action task | The inhibition performance from a rhythmic-action task, expressed as stop-signal reaction time (SSRT, in ms). This latency is measured by identifying a statistical deviation evoked by the STOP signal in the participants' movement on a graphic tablet (following the procedure described in Hervault et al., 2019). | 2 weeks | |
Secondary | Inhibition performance from a discrete-action task | The inhibition performance from a discrete-action task, expressed as an SSRT (in ms). According to the horse-race model of inhibition, this latency is estimated based on the response time and the response probability obtained by the participants when responding to the GO and STOP stimuli used in the task (following recent guidelines from Verbruggen et al., 2019). | 2 weeks |
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