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Atrophy clinical trials

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NCT ID: NCT00599846 Terminated - Clinical trials for Age-Related Macular Degeneration

The Natural History of Geographic Atrophy Progression (GAP) Study

Start date: December 2007
Phase: N/A
Study type: Observational

The objective of the 18-month trial is to evaluate the natural history of geographic atrophy by assessing the rate of progression of the geographic atrophic lesion over time.

NCT ID: NCT00439569 Terminated - Clinical trials for Spinal Muscular Atrophy Type II

Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III

NPTUNE01
Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to identify the maximum tolerated dosage of sodium phenylbutyrate in children with spinal muscular atrophy types II or III; and to determine if the drug has an effect on SMN mRNA and protein levels.

NCT ID: NCT00439218 Terminated - Clinical trials for Spinal Muscular Atrophy Type I

Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I

NPTUNE 02
Start date: January 2008
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to identify the maximum tolerated dosage of sodium phenylbutyrate in children with spinal muscular atrophy type I; and to determine if the drug has an effect on SMN mRNA and protein levels.

NCT ID: NCT00292916 Terminated - Atrophy Clinical Trials

Effect of Whole Body Vibration on Bone and Fall Related Parameters

Start date: January 2006
Phase: Phase 3
Study type: Interventional

The effect of whole body vibration (WBV) on bone strength and fall frequency in older adults is still vague. Although there is some evidence that WBV may impact Bone Mineral Density in very frail elderly, there is a lack of data concerning the effect of WBV in community-living elderly woman. We hypothesize that WBV significantly affects bone parameters as assessed by DXA, QCT, US and bone markers with parallel positive changes of fall related risk factors (power, strength, balance, and reaction time). We further hypothesize that the effects of WBV were superior to conventional resistance exercise.

NCT ID: NCT00267839 Terminated - Atrophy Clinical Trials

Effect of Exercise on Risk-factors of Elderly Women

Start date: January 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether exercise training may impact relevant risk factors and health costs of community living women older 65 years.

NCT ID: NCT00211224 Terminated - Clinical trials for Multiple System Atrophy

Neuroprotection and Natural History in Parkinson's Plus Syndromes (NNIPPS)

Start date: April 2000
Phase: Phase 3
Study type: Interventional

NNIPPS is a clinical trial of riluzole (a drug previously shown to slow down the rate of progression og amyotrophic lateral sclerosis-ALS; Lou Gehrig's disease) involving nearly 800 people diagnosed with the 'parkinson plus' syndromes of multiple system atrophy (MSA) and progressive supranuclear plasy (PSP). In addition to showing whether riluzole is helpful in MSA and PSP, NNIPPS will improve criteria for making an accurate and early diagnosis, for assessing the rate of progression, and will advance understanding of the biology of these disabling and progressive neurodegenerative diseases.