Atrophy, Muscular Clinical Trial
Official title:
Investigating the Effect of Neuromuscular Electrical Stimulation and Blood Flow Restriction Training on Physiological Deconditioning During Unloading and Retraining
Following injury or surgery to a limb, it is often immobilised to allow tissue healing. Short periods of disuse cause loss of muscle size and strength and impaired mechanical properties of tendons, which leads to reduced function. Strategies to combat these deconditioning adaptations include neuromuscular electrical stimulation (NMES), however at present its effectiveness is limited. Recent research suggests that the effects of NMES can be augmented with blood flow restriction (BFR). At present, the effect of combining these two techniques on muscle function during limb immobilisation is unknown. Furthermore, the impact of BFR training during retraining following immobilisation is unknown.
Status | Not yet recruiting |
Enrollment | 36 |
Est. completion date | October 1, 2023 |
Est. primary completion date | October 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 55 Years |
Eligibility | Inclusion Criteria: - Between the age of 18-55 - Non-smoker - No previous history of cardiovascular, respiratory or neurological problems - Not taking anticoagulant medication - Injury-free in the 3 months prior to scheduled participation in the study. Exclusion Criteria: - Hypertension (<140/80) - Metal work in-situ - Blood diseases or clotting issues - Injury or previous injury (<3 months prior to scheduled participation in the study) - Pregnancy |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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St Mary's University College |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in maximal isometric strength via Biodex Dynamometer | Strength measure | Through study completion, an average of 1 year | |
Primary | Change in maximal isokinetic strength via Biodex Dynamometer | Strength measure | Through study completion, an average of 1 year | |
Secondary | Change in muscle endurance via Biodex Dynamometer | Endurance measure | Through study completion, an average of 1 year | |
Secondary | Change in muscle morphology via 2D and 3D ultrasonography | Morphology measure | Through study completion, an average of 1 year | |
Secondary | Change in muscle VO2 via near-infrared spectroscopy | VO2 measure | Through study completion, an average of 1 year | |
Secondary | Change in blood markers via venous blood samples | Blood markers | Through study completion, an average of 1 year | |
Secondary | Change in pressure pain thresholds via handheld allometry | Pain measure | Through study completion, an average of 1 year | |
Secondary | Change in corticomotor excitability and inhibition, via transcranial magnetic stimulation | Corticospinal function | Through study completion, an average of 1 year |
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