Atrophic Vaginitis Clinical Trial
Official title:
A Comparative Study of Vaginal Oestrogen Cream and Platelet Rich Plasma in Treatment of Atrophic Vaginitis in Fayoum University Hospital
This study is designed to compare the efficacy, acceptability, and safety of vaginal estrogen cream and platelet-rich plasma in pt. complaining of atrophic vaginitis.
Oestrogen deficiency affects many organs such as the genitourinary system. Genitourinary involvement causes untoward symptoms of atrophic vaginitis including dryness, burning, dyspareunia, vulvar pruritus, and discharge For this reason, many investigations have been performed to find out effective, safe, and acceptable therapeutic methods for atrophic vaginitis. Although systemic administration of estrogen can improve the localized symptoms of atrophic vaginitis, women are often reluctant to use systemic hormone replacement therapy and prefer local administration of estrogen. Vaginal application of estrogen has been considered an effective treatment of atrophic vaginitis. The effects of PRP treatment have been evaluated in many clinical conditions, including wound healing, hair repair, skin regeneration [9], vulvar lichen sclerosis, stress urinary incontinence, episiotomy scars, and lubrication aging in the vagina. It can take at least 12 weeks to determine the final effects of treatment with PRP Population of Study It includes 100 pt. complaining of atrophic vaginitis it will be divided into two groups, each group will contain 50 pt Methodology in detail: Patients of the first group will receive vaginal estrogen cream one tube every night for 14 nights; then, one tube 2 nights in 1 week (two tubes every week) for 10 weeks. The second group will receive PRP injection every 3 weeks for 4 times. PRP will be administered to the anterior vaginal wall using 27-G needles once every 3 weeks for 4 times and PRP is mainly injected into the clitoris or the anterior wall of the vagina to increase the tactile sensitivity of the injection site. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00984399 -
Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen
|
N/A | |
| Completed |
NCT04079218 -
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
|
Phase 4 | |
| Recruiting |
NCT05953090 -
VALOR: Vaginal Atrophy & Long-term Observation of Recovery
|
N/A | |
| Terminated |
NCT00816556 -
A Trial to Evaluate the Efficacy of Low Dose Vaginal Estrogens in the Treatment of Atrophic Vaginitis
|
Phase 3 | |
| Completed |
NCT00167921 -
Study Comparing Premarin® Vaginal Cream Versus Premarin® Oral Tablets in Atrophic Vaginitis
|
Phase 1 | |
| Completed |
NCT04327947 -
Evaluation of Gynecological Acceptability of 3 Health Care Products
|
N/A | |
| Completed |
NCT03294538 -
Study to Evaluate Equivalence of Estradiol Vaginal Cream 0.01% to Estrace® Cream 0.01% in Atrophic Vaginitis
|
Phase 3 | |
| Completed |
NCT05058313 -
Evaluation of the Safety and Performance of the MILTA GYNECO Vaginal Probe in Postmenopausal Women With Vaginal Atrophy
|
N/A | |
| Completed |
NCT02995694 -
A Study Comparing Estradiol Vaginal Cream to Estrace® Cream in Females With Atrophic Vaginitis
|
Phase 3 | |
| Completed |
NCT02691936 -
Comparison of Vaginal Laser Therapy to Vaginal Estrogen Therapy
|
N/A | |
| Recruiting |
NCT06305494 -
Genitourinary Syndrome of Menopause in Thai Gynecologic Cancer Survivors
|
||
| Completed |
NCT02195986 -
A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis
|
Phase 3 | |
| Recruiting |
NCT03981458 -
Hyaluronate for the Treatment and Prevention of Recurrent Urinary Tract Infection in Women Suffering Atrophic Vaginitis
|
N/A | |
| Completed |
NCT05396261 -
a Flexible Wound Dressing for the Management of Genital Skin Conditions
|
N/A | |
| Completed |
NCT02869165 -
Vaginal and Urinary Microbiome Trial
|
Phase 4 | |
| Completed |
NCT02029053 -
Preliminary Study of a Vaginal Lubrication Ring to Treat the Symptoms of Vaginal Dryness
|
Phase 0 | |
| Not yet recruiting |
NCT06176820 -
Vaginal Hyaluronic Acid, Arginine and Liposome Gel Versus Vaginal Lubricant in Postmenopausal Women With Genitourinary Syndrome of Menopause
|
Phase 2/Phase 3 | |
| Recruiting |
NCT02733731 -
The Treatment Effect of Chinese Herbal Compound Ointment on Atrophic Vaginitis
|
Phase 1 | |
| Withdrawn |
NCT02460302 -
Vaginal Progesterone Versus Placebo for the Treatment of Vaginal Atrophy
|
Phase 2 | |
| Completed |
NCT02313545 -
Phase I-B Study to Evaluate the Safety, Tolerability and Efficacy of IZN-6NVS for the Treatment of AV and DIV
|
Phase 1/Phase 2 |