Treatment of Atrophic Acne Scars With Platelet-Rich Plasma and Skin Needling

Atrophic Acne Scars Clinical Trial

Official title:

Treatment of Atrophic Acne Scars With Platelet-Rich Plasma Alone or in Combination With Skin Needling: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02798016
• Other study ID #: UDMS-Dermat-01-2016
• Status: Completed
• Phase: N/A
• First received: May 13, 2016
• Last updated: December 31, 2017
• Start date: October 2015
• Est. completion date: October 20, 2017

Study information

• Verified date: December 2017
• Source: Damascus University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Investigators will collect blood specimens from the participating patients and then blood samples will be centrifuged in order to collect platelet-rich plasma which is going to be injected in the atrophic acne scars. A split-face design is going to used in this randomized controlled trial. In the control side of the face, micro-needling to the skin will occur using a specific tool (Dermapen).

Description:

Atrophic acne scar is a common problem with a challenging treatment. Platelet-rich plasma (PRP) is an autologous preparation of platelets in concentrated plasma that may be beneficial in the treatment of atrophic acne scars by promoting collagen deposition.

Skin needling is a technique that uses a sterile micro needles to puncture the skin and release growth factors. The combination of skin needling and PRP could enhance the efficacy of both modalities.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: October 20, 2017
• Est. primary completion date: June 23, 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Atrophic acne scars on both sides of the face

Exclusion Criteria:

• patients with active acne, herpes labialis, or bacterial infection; warts on the face, actinic keratosis, or skin cancer

• systemic retinoids intake in the previous 6 months,

• diabetes, pregnancy, history of keloidal scarring; or patients with severe systemic illness or malignancy

• patients on anticoagulant therapy or aspirin or have a coagulation issue,

• patients with hemoglobin less than 10g\dl or platelet less than 105 micron\l

• any previous procedures for acne scar within the last 6 months

Related Conditions & MeSH terms

• Atrophic Acne Scars
• Atrophy

Intervention

Procedure:
• Platelet-Rich Plasma
This Platelet-Rich Plasma will be taken from each patient and is going to be used in the treatment of atrophic acne scars
• Micro-needling
Micro-needling will be applied on the acne scars in one side of the face.

Locations

Country	Name	City	State
Syrian Arab Republic	Department of Dermatology and Venereology	Damascus

Sponsors (1)

Lead Sponsor	Collaborator
Damascus University

Country where clinical trial is conducted

Syrian Arab Republic, 

References & Publications (4)

Cunliffe WJ, Gould DJ. Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J. 1979 Apr 28;1(6171):1109-10. — View Citation

Goulden V, Stables GI, Cunliffe WJ. Prevalence of facial acne in adults. J Am Acad Dermatol. 1999 Oct;41(4):577-80. — View Citation

Layton AM, Henderson CA, Cunliffe WJ. A clinical evaluation of acne scarring and its incidence. Clin Exp Dermatol. 1994 Jul;19(4):303-8. — View Citation

Sunitha Raja V, Munirathnam Naidu E. Platelet-rich fibrin: evolution of a second-generation platelet concentrate. Indian J Dent Res. 2008 Jan-Mar;19(1):42-6. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Scar Appearance		Scar Appearance will be assessed at: T1; one day (wihtin 24 hours) before the application of the intervention(s); and T2: after three months of applying the intervention(s).
Secondary	Patients' Satisfaction	The assessment will be based on a questionnaire	This is going to be assessed six months following the application of the intervention and the active comparator