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Efficacy of Intralesional Injection of Pentoxifylline, Platelet-Rich Plasma, and Combined Pentoxifylline With Platelet-Rich Plasma in Patients With Atrophic Acne Scars

Atrophic Acne Scar Clinical Trial

Official title:
Efficacy of Intralesional Injection of Pentoxifylline, Platelet-Rich Plasma, and Combined

Clinical Trial Summary

Platelet-rich plasma (PRP) is an Acne vulgaris is a common chronic inflammatory skin disorder. It is the eighth most prevalent disease worldwide with a prevalence of 9.4%. Acne scar is one of the most persistent complications of acne, causes marked psychological stress to the patient . The process of acne scar formation can be broadly divided into two stages: increased tissue formation and loss or damage of tissue, corresponding to keloid or hypertrophic scar and atrophic scar, respectively. The ultimate severity of acne scars is correlated with acne grade and the delay in treatment of active disease. The atrophic scars include three subtypes: icepick or V-shaped, rolling or M-shaped, and boxcar or U-shaped scars. Among atrophic scars, the ice pick type represents 60%-70%; the boxcar type represents 20%-30%; and the rolling type represents 15%-25% (Salameh and Shumaker, 2022). According to the qualitative scarring grading system, a macular acne scar type also exists, which clinically shows erythematous, hyperpigmented, or hypopigmented flat marks. autologous blood product containing high concentrations of platelets in a small volume of plasma. PRP has been utilized in the treatment of orthopedic, musculoskeletal, and maxillofacial conditions for many years, it has only recently gained popularity in dermatology. PRP contains various growth factors, including platelet-derived growth factor (PDGF), transforming growth factor (TFG), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF). These growth factors stimulate tissue remodeling and are associated with enhanced healing through the attraction of macrophages, upregulation of collagen synthesis, and promotion of tissue regeneration. Moreover, platelet-derived growth factor (PDGF) was shown to promote wound healing, angiogenesis, and tissue remodeling.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06319768
Study type Interventional
Source Sohag University
Contact MARIAM M SOLIMAN, resident
Phone 01151180969
Email mariam-mosaad-post@med.sohag.edu.eg
Status Recruiting
Phase N/A
Start date January 1, 2024
Completion date June 15, 2024
View Details
See also
  Status Clinical Trial Phase
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Not yet recruiting NCT05105334 - Combined Therapy for Acne Scars N/A
Completed NCT05413200 - Investigation of the Effect of Oral Isotretinoin on Skin Thickness and Elasticity in Patients With Atrophic Acne Scar
Completed NCT03056235 - A Study to Evaluate the Efficacy of ELAPR002f in Females and Males With Atrophic Acne Scars N/A
Completed NCT04829370 - Clinical Application of Patented Lyophilized PLT in Acne Scar Repairment. N/A
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Recruiting NCT04813419 - 2940nm Er:YAG Laser and 1927nm Thulium Laser in Improving Atrophic Acne Scars N/A
Recruiting NCT04580758 - Fractional CO2 Laser Combined With PRP Fluid Versus Gel in Treatment of Acne Scars Early Phase 1
Completed NCT01559922 - Use of Artefill® for Moderate to Severe Atrophic Acne Scar Correction Phase 3
Completed NCT04740268 - Straberi Microneedling For Atrophic Acne N/A
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