Half-normal Saline in Atrial Flutter Ablation

Status Completed

Clinical Trial Summary

To assess the acute and long-term efficacy of half-normal saline compared to normal saline for irrigation of open-irrigated catheters during catheter ablation for the treatment of cavotricuspid isthmus dependent atrial flutter.

Clinical Trial Description

It is unclear whether ionic strength affects energy delivery and ablation lesion size during radiofrequency ablation for atrial flutter. Given that saline contains ionic sodium and chloride in the solution, it has conductive properties that may disperse radiofrequency energy away from the tip-tissue interface, thereby reducing current density and lesion size compared to ablation with nonionic solutions. The efficacy of half-normal saline will be measured by the time taken to create bidirectional block across the cavotricuspid isthmus as well as the acute recurrence rate within 30 minutes of the initial occurrence of bidirectional block and the 1 year freedom from flutter recurrence. ;

Study Design

Related Conditions & MeSH terms

Atrial Flutter

Clinical Trial Details

NCT number	NCT04001530
Study type	Interventional
Source	Sunnybrook Health Sciences Centre
Contact
Status	Completed
Phase	N/A
Start date	January 1, 2018
Completion date	January 31, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05416086` - iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study	N/A
Terminated	`NCT02317029` - Comparison of Oxygen Interventions and Defibrillator Efficiency	N/A
Recruiting	`NCT01563848` - Cryoablation in Patients With Atrial Flutter	Phase 2
Completed	`NCT01229254` - Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation or Atrial Flutter	Phase 2
Completed	`NCT00839657` - Clarification of Optimal Anticoagulation Through Genetics	Phase 3
Completed	`NCT02065388` - Pharmacogenetic Dosing of Warfarin	Phase 3
Completed	`NCT00232232` - Use of Fish Oils to Prevent Atrial Mechanical Stunning and Atrial Remodeling Due to Atrial Arrhythmia	Phase 4
Completed	`NCT04884100` - enHEART - Exploring Full Content of Optical Signals to Enhance Cardiac Arrhythmia Screening	N/A
Completed	`NCT05468281` - RAFF5 Proposal: Improve the Quality and Safety of Patients Seen in the Emergency Department for Acute Atrial Fibrillation and Flutter
Completed	`NCT03627143` - Decreasing Hospital Admissions From the ED for AAFF	N/A
Completed	`NCT02917538` - A Randomized Trial of Contact Force in Atrial Flutter Ablation	N/A
Enrolling by invitation	`NCT05903313` - A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software
Recruiting	`NCT05755074` - Ablation of Typical Right Atrial Flutter	N/A
Recruiting	`NCT05883631` - RESOLVE-AF: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy.	N/A
Recruiting	`NCT03272620` - Atrial Fibrillation at the Viennese University Emergency Department	N/A
Completed	`NCT02810938` - MIFI Flutter Registry - Ablation of Atrial Flutter With IntellaTip Sensor Technology
Recruiting	`NCT02591875` - Atrial Flutter Ablation in a Real World Population	N/A
Completed	`NCT01914497` - Dipole Density Mapping of Typical Atrial Flutter	N/A
Completed	`NCT02268799` - High Sensitivity Troponin T Levels Following DC Cardioversion for Atrial Fibrillation / Atrial Flutter	N/A
Active, not recruiting	`NCT01976507` - Use of Dabigatran Etexilate to Prevent Stroke and Thromboembolism	Phase 4