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Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients

Atopic Dermatitis Clinical Trial

Official title:
Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients

Clinical Trial Summary

Our hypothesis is that S. aureus skin decolonization in atopic dermatitis reduces disease severity and favorably alters the function and gene expression of epidermal and immune skin cells that contribute to disease severity.

Clinical Trial Description

Patients will sign an informed consent and assent to participate. Skin and both nares will be cultured for S aureus. A blood sample and two 2 mm skin biopsies will be obtained one from non-lesional skin and another one from lesional skin). The patients will be instructed in the use of the three-week S. aureus decolonization regimen and provided with the medications (sulfamethoxazole/trimethoprim and Mupirocin ointment) and Chlorhexidine. The second visit will take place immediately at the end of the three-week S. aureus skin decolonization regimen. Disease severity will be assessed, the skin and nares will be re-cultured, and skin biopsies and blood will be obtained. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06397781
Study type Interventional
Source Boston Children's Hospital
Contact
Status Not yet recruiting
Phase Phase 4
Start date May 1, 2024
Completion date July 1, 2028
View Details
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