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Prenatal Exposure to Emerging Contaminants and Children's Atopic Dermatitis — PECCAD  

Atopic Dermatitis Clinical Trial

Official title:
Prenatal Exposure to Emerging Contaminants and Offspring's Atopic Dermatitis (PECCAD)

Clinical Trial Summary

This prospective cohort study aims to investigate the association between prenatal blood levels of Emerging Contaminants and the five-year incidence of atopic dermatitis (AD) in offspring.

Clinical Trial Description

This prospective birth cohort study, conducted within the Shanghai prenatal population, involves the collection of maternal blood samples during gestation to directly measure the biological exposure levels of Emerging Contaminants, including Per- and Polyfluoroalkyl Substances (PFAS), Organophosphate Flame Retardants (OPFRs), and Microplastics. Serum and whole blood levels of these contaminants are evaluated during pregnancy at 12-14, 22-26, and 31-34 gestational weeks. Subsequently, the study assesses skin barrier function in infants at 24-48 hours, 42 days, and 6 months of age. During a five-year period, the occurrence of atopic dermatitis (AD) in offspring is assessed. The objectives of this cohort study are twofold: (1) to elucidate the relationship between maternal exposure to Emerging Contaminants and the development of AD in offspring, and (2) to evaluate the impact of such exposure on the skin barrier function of infants. This research aims to provide substantial evidence for the prevention of AD, offering a unique and meaningful approach to mitigating the incidence of AD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06316609
Study type Observational [Patient Registry]
Source Children's Hospital of Fudan University
Contact
Status Active, not recruiting
Phase
Start date June 2016
Completion date December 31, 2027
View Details
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