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Optimization of Cyclosporin in Atopic Dermatitis Through Multiomic Predictive Models of Treatment Response — DermAtOmics  

Atopic Dermatitis Clinical Trial

Official title:
Optimization of Cyclosporin Therapy in Atopic Dermatitis Through Multiomic Predictive Models of Treatment Response (DermAtOmics)

Clinical Trial Summary

This is a low-intervention phase IV trial. The main objective is to optimize the treatment of patients with moderate-severe atopic dermatitis who require systemic treatment.

Clinical Trial Description

Primary outcome is the percentage of patients with primary non- response to treatment with cyclosporin. Defined as fail to achieve EASI-75 (a 75% improvement in EASI score) at week 16 of follow-up. A 12-month recruitment period is planned and about of 100 patients with moderate-severe atopic dermatitis will be recruited. The study is divided into two cohorts. All patients diagnosed with moderate-severe atopic dermatitis who are going to receive treatment with cyclosporin in the Dermatology Service of La Paz University Hospital and associated Specialty Centers are selected in cohort 1. Patients will receive the starting dose used in routine clinical practice. All patients diagnosed with moderate-severe atopic dermatitis who are receiving or have received cyclosporin therapy in the Dermatology Service of La Paz University Hospital and associated Specialty Centers are selected in cohort 2. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05692843
Study type Interventional
Source Instituto de Investigación Hospital Universitario La Paz
Contact Alberto M Borobia, MD, PhD
Phone +34-917277558
Email alberto.borobia@salud.madrid.org
Status Recruiting
Phase Phase 4
Start date October 10, 2022
Completion date July 2024
View Details
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