Atopic Dermatitis Clinical Trial
Official title:
Effect of Holly Mangrove Shower Gel Containing Acanthus Ebracteatus Vahl. on Skin Barrier Function in Atopic Dermatitis Patients
Atopic dermatitis is a chronic intermittent inflammatory skin disease. Currently, there are
many cosmeceutical skin products in which their major action affects skin hydration and skin
barrier function. In addition, there are some herbal medication remedies used for the
treatment of skin diseases based on the knowledge of Thai traditional medicine. Patients
with pruritic rash symptoms who attended the Center of Applied Thai Traditional Medicine,
Siriraj Hospital, were prescribed the Holly Mangrove Shower Gel to use and on the follow-up
appointment showed significant improvement. Nevertheless, the knowledge of using this herbal
medication for treating pruritic skin rash so far has been categorized as folk wisdom and
not been confirmed by any clinical-trial study on its efficacy and mechanism of action.
Research teams chose Holly Mangrove Shower Gel containing Acanthus ebracteatus Vahl to act
as adjunctive for treating atopic dermatitis. Thus, for the purpose of studying the efficacy
of Holly Mangrove Shower Gel containing Acanthus ebracteatus Vahl in improving the skin
barrier function in atopic dermatitis.
The investigators team research with patients by separate patients into 2 groups and compare among each other. In the first group use placebo, the other group use Holly Mangrove Shower Gel. To compare outcomes, the investigators will measure transepidermal water loss, stratum corneum hydration, skin pH, sebum and wrinkles after using studied gel. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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