Stool Microbiome, Pathogens, and Infectious Agents Among Olympic and Elite Athletes

Athletic Performance Clinical Trial

— TRMC-Bio  

Official title:

TRMC-Bio "Molecular Profiling of Gut Microbiome, Microbiome Metabolome, Serum Chemistry, and Metabolism-Associated SNPs in Elite Athletes"

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02818413
• Other study ID #: 16-001515
• Status: Completed
• Phase: N/A
• First received: June 28, 2016
• Last updated: August 28, 2017
• Start date: June 3, 2016
• Est. completion date: March 21, 2017

Study information

• Verified date: August 2017
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This research is being done to investigate fecal microbiome and metabolome as well as serum analytes and single nucleotide polymorphisms in Olympic athletes in comparison with other elite athletes.

Description:

Olympic athletes, non-Olympic elite athletes, and other active adults may have genetic and metabolic profiles that are unique. These profiles may contribute to the caliber of their athletic performance, and they may provide keys to understanding select genetic and metabolic conditions.

Therefore, the specific aims of this project are as follows:

• Specific Aim 1: Characterize the fecal microbial communities in athletes participating in the summer 2016 games and in athletes not participating in the Olympic games

• Specific Aim 2: Characterize the fecal microbiome metabolome (untargeted) in athletes participating in the summer 2016 games and in athletes not participating in the Olympic games

• Specific Aim 3: Characterize selected serum analytes and single nucleotide polymorphisms (SNPs) of elite athletes participating in the Summer 2016 games and in athletes not participating in the Olympic games, via serum and saliva analyses, respectively

• Specific Aim 4: Retain specimens from Olympic athletes participating in the summer 2016 games and in athletes not participating in the Olympic games for future research

• Specific Aim 7: Examine for the presence of Zika virus RNA in study participants who exhibit symptoms

Stool, urine, and blood specimens will be collected to study the stool metabolome, as well as serum analytes and single nucleotide polymorphisms, and the nature and extent of exposure to pathogens and infectious agents. These will be compared between Olympic athletes and other non-Olympic elite athletes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: March 21, 2017
• Est. primary completion date: March 21, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Member of the Summer 2016 U.S. Olympic team and/or other elite athlete

• English speaking

• Willing to provide informed consent and biospecimens

• Willing to complete questionnaires regarding normal bowel habits and general health

Exclusion Criteria:

Related Conditions & MeSH terms

• Athletic Performance

Intervention

Other:
• Biospecimen collection and questionnaires
Biospecimen collection and questionnaires

Locations

Country	Name	City	State
United States	Mayo Clinic	Rochester	Minnesota

Sponsors (2)

Lead Sponsor	Collaborator
Mayo Clinic	Thorne Research Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Baseline identification of microbial community present in stool		Approximately 1 week after collection of stool sample