Athletes Clinical Trial
Official title:
Long-term Effect of Combined Citrulline and Nitrate-rich Beetroot Extract Supplementation on Recovery Status in Trained Male Triathletes
Verified date | November 2021 |
Source | Burgos Nutrition |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Citrulline (CIT) and nitrate-rich beetroot extract (BEET) are widely studied ergogenic aids. However, both supplements have been studied in sort-term and isolated. To the best of the authors' knowledge, the effects of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have not been investigated to date. Therefore, the main purpose of this study was to determine the effect and degree of potentiation of the long-term (9 weeks) mixture of 3 g/day of CIT plus 2.1 g/day of BEET (300 mg/day of NIT) supplementation on EIMD markers (urea, creatinine, AST, ALT, GGT, LDH and CK) and anabolic/catabolic hormone status (testosterone, cortisol and Testosterone cortisol ratio (T/C)) in male trained triathletes. This study was a double-blind, placebo-controlled trial where participants (n = 32) were randomized into 4 different groups: placebo group (PLG; n = 8), CIT group (CITG; 3 g/day of CIT; n = 8), BEET group (BEETG; 2.1 g/day of BEET (300 mg/day of NIT) ; n = 8) and CIT-NIT group (CIT-BEETG; 3 g/day of CIT plus 2.1 g/day of BEET (300 mg/day of NIT); n = 8). Blood samples were collected from all participants at baseline (T1) and after 9 weeks of supplementation (T2).
Status | Completed |
Enrollment | 32 |
Est. completion date | October 1, 2021 |
Est. primary completion date | August 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 25 Years to 35 Years |
Eligibility | Inclusion Criteria: - Males between 25 and 35 years old - Triathletes - With at least 5 years of experience - Without any disease - Non smokers - Non drinkers of alcohol - Not to take any other medications or stimulant substances during the study - 2 weeks without taking other nutritional supplements Exclusion Criteria: - Exclusion criteria: - Men under 25 and over 35 years of age. - Non triathletes - Less than 5 years of experience - With any disease - Smokers - Alcohol drinkers |
Country | Name | City | State |
---|---|---|---|
Spain | University of Leon | León | Castilla Y León |
Lead Sponsor | Collaborator |
---|---|
Burgos Nutrition | Universidad de León, University of the Basque Country (UPV/EHU), University of Valladolid |
Spain,
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* Note: There are 20 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cortisol | µg/dL | 9 weeks | |
Primary | Testosterone | ng/mL | 9 weeks | |
Primary | Testosterone to cortisol ratio | ng/mL | 9 weeks | |
Primary | Urea | mg/dl | 9 weeks | |
Primary | Creatinine | mg/dl | 9 weeks | |
Primary | AST | U/L | 9 weeks | |
Primary | ALT | U/L | 9 weeks | |
Primary | GGT | U/L | 9 weeks | |
Primary | LDH | U/L | 9 weeks | |
Primary | CK | U/L | 9 weeks |
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