Athletes Foot Clinical Trial
Official title:
Beneficial Effect of Curcuma Extract In Muscle Damage (Study in Soccer Athlete): Randomized Clinical Trial
Muscle damage and inflammation is a clinical problem caused by the unimpeachable body adaptation of strenuous exercise through increasing free radicals. Antioxidants content in Curcuma is hypothesized to alleviate the free radicals. This study aimed to examine the effect of Curcuma extract in the form of ice cream to improve muscle damage and inflammation of soccer athletes caused by strenuous exercise. This study was experimental study with pre-post control group design. Male soccer athlete (n=20) were divided into treatment group (n=10) and control group (n=10). The treatment group was treated by Curcuma extract ice cream for 21 days. Blood samples of creatine kinase (as muscle damage marker) and IL-6 (as inflammation marker) were quantified.
Muscle damage is a clinical problem caused by the adaptation process in strenuous exercise of
soccer athletes which free radical is the main culprit of the damage. There is a significant
increment of muscle damage after strength exercise using leg press. Physical exercise leads
to inflammation process in endothelial cells of blood vessel which can be marked by releasing
cytokine. Interleukin-6 (IL-6) is one of cytokine pro-inflammation and this marker is used as
an indicator for inflammation of micro-trauma in muscle during strenuous exercise.
Normally, free radical generation will be stabilized by endogenous antioxidant secretion such
as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase; nevertheless, body
needs exogenous antioxidant to support endogenous antioxidant as a scavenger of free radical
in such condition.
Muscle damage due to the strenuous exercise should be managed to avoid the pain feeling and
subsequently decrease athlete performances. Some previous studies used herbs such as ginger
(Zingiber officinale), ginseng (Panax quinquefolium), and Curcuma to relieve the muscle
damage and inflammation resulting from high-intensity exercise.The Curcuma extract treatment
to the athlete gained lack of success; therefore, supplementation to food products might use
to increase acceptability. Ice cream is one of the products, which has a broad segment market
and every single person regardless of age is fond of it.
Curcumin is an antioxidant substance contained in Curcuma and it has better antioxidant
capacity compared to the other component in Curcuma such as demetoksicurcumin and
bisdemetoksicurcumin.Besides, curcumin has an efficient reaction with superoxide radicals as
well as lipid antioxidants has, and the reaction leads to superoxide catalytic degradation in
which curcumin represents as a superoxide dismutase. This study aimed to examine the Curcuma
extract effect which has been supplemented to own-made ice cream in muscle damage and
inflammation of soccer athletes after having strenuous exercise.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04568577 -
Effects of the Elastic Taping on the Chronic Ankle Instability
|
N/A |