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Atheroscleroses, Coronary clinical trials

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NCT ID: NCT06182683 Recruiting - Clinical trials for Coronary Artery Disease

Concurrent OCT and FFR-guided PCI in CAD

OPTICARE-CAD
Start date: November 30, 2023
Phase: N/A
Study type: Interventional

The present study is a prospective randomized clinical trial aimed to compare the therapeutic strategy of angiography-guided versus concurrent OCT/FFR-guided intervention in patients with coronary artery disease.

NCT ID: NCT06083337 Recruiting - Clinical trials for Coronary Artery Disease

Vascular Inflammation ReDuction and Perivascular Fat Imaging by Computed Tomography

VIRDICT
Start date: January 22, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare the effect of standard of care management vs. CaRi-Heart based management on vascular inflammation in patients with increased Fat Attenuation Index-Score. The main questions it aims to answer are: - Does treatment intensification reduce vascular inflammation detected by perivascular fat imaging to a greater extent than standard of care treatment? - Do changes in vascular inflammation biomarkers correlate with changes in lipid metrics or inflammatory biomarkers, such as interleukin-6? Participants will be randomized either to standard of care treatment or intensified treatment with maximum dose of atorvastatin +/- low dose of colchicine. After their inclusion, study participants will be followed-up for 6 months with regular monitoring for adverse events and blood will be drawn at 3 and 6 months. After the 6-month follow-up, participants will undergo CCTA imaging for fat attenuation index measurements. Researchers will compare standard of care and vascular inflammation-based treatment to see if inflammation-based treatment is more potent against vascular inflammation.

NCT ID: NCT03894423 Recruiting - Clinical trials for Coronary Artery Bypass

Comprehensive Computed Tomography Guidance of Coronary Bypass Graft Surgery

Start date: May 1, 2019
Phase:
Study type: Observational

Apply CT angiography, CT perfusion imaging and advanced image processing techniques to improve revascularization decision-making and surgical strategies in patients undergoing coronary artery bypass graft surgery.