Atelectasis Clinical Trial
Official title:
High Fresh Gas Flow After Intubation - A Randomized Clinical Trial
Verified date | May 2015 |
Source | Landstinget Västmanland |
Contact | n/a |
Is FDA regulated | No |
Health authority | Sweden: Regional Ethical Review Board |
Study type | Interventional |
Atelectasis is common during and after general anesthesia. Atelectasis develops early if preoxygenation with 100% oxygen is used and continuously used during induction until endotracheal intubation. The investigators hypothesize that a rapid anti-preoxygenation maneuver immediately after confirming a successful intubation, reduces the area of atelectasis as investigated by computed tomography compared to a standard procedure.
Status | Completed |
Enrollment | 24 |
Est. completion date | May 2015 |
Est. primary completion date | May 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 40 Years to 75 Years |
Eligibility |
Inclusion Criteria: - Healthy patients, American Society of Anesthesiology (ASA) I-II - Patients scheduled for orthopaedic day case surgery in general anaesthesia Exclusion Criteria: - ASA class III or higher - Body Mass Index (BMI) 30 or higher - Arterial oxygen saturation (SpO2) <94% breathing air - Chronic Obstructive Pulmonary Disease (COPD) - Ischemic heart disease - Haemoglobin <100g/L - Known or anticipated difficult airway and/or intubation - Active smokers and ex-smokers with a history of more than 6 pack years - Need for interscalene or supraclavicular regional anaesthesia with risk of phrenic nerve paralysis |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Sweden | Landstinget Västmanland | Köping | Västmanland |
Lead Sponsor | Collaborator |
---|---|
Landstinget Västmanland |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Atelectasis | The area of atelectasis in the lungs is assessed by computed tomography (CT) 10 mm above the dome of the right diaphragm and expressed in cm2 and as % of the total lung area in the particular scan. | Within 1-2 hours, just before emergence from anesthesia | Yes |
Secondary | Arterial blood gases | Within 2-3 hours perioperatively | Yes |
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