Atelectasis Clinical Trial
Official title:
Influence of Hyperoxia and Hypergravity on Pulmonary Ventilation and Perfusion
The primary aim of this project is to get further knowledge on the effects of + Gz accelerations and hyperoxia on lung ventilation in humans. The secondary aim is to study lung perfusion and cardiovascular function in these conditions.
Experiments were conducted in a human centrifuge. The protocol aimed at mimicking a routine
peacetime flight in combat aircraft, and included 10-min exposure to +1.4 - +3.5 Gz.
Subjects were exposed three times to this sequence, breathing air, 44.5% O2 or 100% O2.
Ten volunteers wearing anti-G trousers participated in the study. The Ethics Committee
Ile-de-France III and the French National Agency for Drug Safety (ANSM) approved the
protocol (number 2009-A01092-55).
Three different imaging techniques, electrical impedance tomography (EIT), pulmonary
ultrasound and chest SPECT/CT were used and compared. EIT enabled ventilation monitoring in
the human centrifuge, whereas pulmonary ultrasound and SPECT/CT gave functional and
topographical information before and after exposure to +Gz accelerations. EIT analysis
focused on regional ventilation, SPECT on global lung ventilation and perfusion, CT on the
presence of atelectasis, and pulmonary ultrasound analysis looked for comet tails in 64
chest areas. Arterial blood pressure was recorded continuously by finger
photoplethysmography. Cardiac output and stroke volume were computed from these recordings,
using three different algorithms. Echocardiography was used as reference non-invasive
technique for stroke volume determination and performed before and after exposure to +Gz
accelerations.
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Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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