Clinical Trials Logo
  1. Home
  2. Atelectasis
  3. NCT00671723

Dornase Alpha Versus Hypertonic Saline for Lung Atelectasis in Non-Cystic Fibrosis Patients

Atelectasis Clinical Trial

Official title:
Dornase Alpha Versus Hypertonic Saline for Lung Atelectasis

Clinical Trial Summary

Despite the lack of trials proving the efficacy of DNase in non cystic fibrosis patients, it is currently heavily used in this population. In fact, per evidence of barcode scanning via Meditech computer system at OU Medical Center 93% of the DNase prescribed in 2005 was for non Cystic fibrosis patients with an estimated yearly cost of $341,968.15.In vitro studies showed that the effect of Dnase was minimal on sputum viscosity when compared to Hypertonic saline . Furthermore recent studies on hypertonic saline in cystic fibrosis patients showed that it is an inexpensive and safe therapy when preceded by a bronchodilator in patients with cystic fibrosis.

We hereby propose a prospective randomized trial to compare the efficacy of hypertonic saline, DNase, vs. normal saline in the treatment of atelectasis in non cystic fibrosis, mechanically ventilated patient.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00671723
Study type Interventional
Source University of Oklahoma
Contact
Status Completed
Phase N/A
Start date October 2006
Completion date July 2008
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06021249 - Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients N/A
Terminated NCT03581474 - Evaluation of BAL Procedure With Ambu aScope 3 Large in Patients in an ICU Setting N/A
Completed NCT02871258 - MetaNeb® Chest X-ray Study N/A
Completed NCT02523755 - Evaluation of Regional Distribution of Ventilation During Labor With or Without Epidural Analgesia Phase 4
Completed NCT02216006 - High Fresh Gas Flow After Intubation N/A
Completed NCT02232841 - Electrical Impedance Imaging of Patients on Mechanical Ventilation N/A
Completed NCT01416519 - Physiotherapy Technique Decreases Respiratory Complications After Cardiac Operation N/A
Completed NCT03153592 - Effects of Mechanical Ventilation Guided by Transpulmonary Pressure on Gas Exchange During Robotic Surgery: a Pilot Study N/A
Completed NCT03694665 - Monitoring Lung Recruitment Maneuver in Anesthetized Morbidly Obese N/A
Completed NCT04506203 - The Accuracy of Pediatric Air Test as a Non-invasive Atelectasis Diagnostic Tool N/A
Not yet recruiting NCT06296173 - Open Lung Protective Extubation Following General Anesthesia N/A
Completed NCT04006665 - Role of Lung Ultrasonography in Diagnosing Atelectasis in Robotic Pelvic Surgeries
Completed NCT03614845 - Evaluation of Effect of Different Ventilator Mods on Atelectasis in Patients Undergoing Laparoscopic Surgery N/A
Active, not recruiting NCT06075836 - AI Assisted Detection of Chest X-Rays
Completed NCT01993394 - Effect of Hyperoxia and Hypergravity on Lung Ventilation and Perfusion N/A
Completed NCT03378752 - Atelectasis Formation Using HFJV During Stereotactic Solid Organ Ablations
Completed NCT05963945 - Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
Completed NCT03592589 - Prevention of Atelectasis, Via High Flow Nasal Cannula to Obtain a PEP, During General Anesthesia in Children N/A
Completed NCT04458623 - Air Test In Diagnosis Of Postoperative Lung Atelectasis N/A
Recruiting NCT05710419 - Effects of Invasive Mechanical Ventilation on the Right Ventricular Function