Ataxia-Telangiectasia Clinical Trial
Official title:
Pilot Study I for Treatment of Cancer in Children With Ataxia-Telangiectasia
This is a pilot/feasibility study designed to investigate the feasibility of treating children with Ataxia-Telangiectasia (A-T) and cancer with regimens nearly as intense as non-A-T patients with cancer would receive.
Approximately 10-30% of A-T patients will develop a malignancy during their lifetime. The
vast majority of these cancers are of lymphoid origin. There is no consensus regarding the
optimal strategy for treating children with A-T who develop hematopoietic malignancies.
Historically, many of these children have been treated with therapy that is much less
intensive than the conventional approach for non-A-T patients with similar malignancies
during the corresponding treatment era. Although these less intensive approaches may have
stemmed from perceptions that these children would not tolerate intensive therapy, there is
in fact no data to suggest that these children cannot tolerate intensive therapy. However,
it is clear that children with A-T require a modification in certain components of intensive
therapy.
To provide children with A-T and either ALL or malignant lymphoma the best chance for a
cure, we propose to use modern therapeutic strategies with minimal modifications which
address the unique toxicity profile encountered in treating children with A-T.
Secondary objectives include:
- To clinically and biologically characterize the malignancies occurring in children with
A-T (usually malignant lymphoma or ALL). This will include in vitro drug sensitivity
screening.
- To study chemotherapy-induced DNA damage in children with A-T.
Detailed Description of Treatment Plan:
- Acute Lymphoblastic Leukemia (ALL) Low Risk:
Induction:
Prednisone 40 mg/m2/day PO days 1-28
Vinblastine 6 mg/m2/dose IV day 8
Vincristine 1.5 mg/m2/dose days 1, 15
Daunomycin 20 mg/m2/week IV days 1,15
Asparaginase 10,000 U/m2/dose IM days 2, 4, 6, 8, 10, 12
VP-16 225 mg/m2/dose Days 22, 25, 29
Ara-C 300 mg/m2/dose Days 22, 25, 29
All patients will receive CNS therapy with triple intrathecal therapy on days 1, 22 and 43
of induction treatment, dose age adjusted.
Consolidation:
Methotrexate 2 mg/m2 IV day 43 and 50 and mercaptopurine 75 mg/m2 days 43-56.
Continuation therapy (120 weeks):
Week:
1. 6-MP + MTX
2. 6-MP + MTX
3. 6-MP + MTX
4. Dex + VCR
5. 6-MP + MTX
6. 6-MP + MTX
7. 6-MP + HDMTX
8. Dex + VCR
9. 6-MP + MTX
10. 6-MP + MTX
11. 6-MP + MTX
12. Dex + VCR
13. 6-MP + MTX
14. 6-MP + MTX
15. 6-MP + HDMTX
This sequence will be repeated through week 52 after which 6-MP + MTX will be given weekly
to complete 120 weeks. IT MHA (MTX, hydrocortisone, Ara-C) on weeks 1, 2, 7, and 15 and then
every 4-8 weeks depending on CNS status.
Dosages, Schedules and Routes:
6-MP 75 mg/m2 PO; daily x 7
MTX 40 mg/m2 IM or IV; q (every) week;
Dex 6 mg/m2 PO; in 3 divided doses daily x 7
VCR 1.5 mg/m2 IV (max. 2.0 mg)
HDMTX 2 g/m2 IV over 2 hours, every 8 weeks
Reinduction:
Reinduction therapy (weeks 16-21). Reinduction therapy (same as initial induction treatment
minus dose 2 and 3 of VP16 +ara-C and minus day 22 intrathecal therapy) will be given after
bone marrow examination on week 15 confirms complete remission.
- Acute Lymphoblastic Leukemia (ALL) - High Risk
Induction:
Prednisone 40 mg/m2/day PO) divided in 3 doses days 1-28
Vinblastine 6 mg/m2/dose IV day 8
Vincristine 1.5 mg/m2/dose days 1, 15
Daunomycin 20 mg/m2/week IV days 1, 15
Asparaginase 10,000 U/m2/dose IM days 2, 4, 6, 8, 10, 12, (15, 17, 19)
VP16 225 mg/m2/dose days 22, 25, 29
Ara-C 300 mg/m2/dose days 22,25,29
All patients will receive triple IT therapy on days 1, 22 and 43 of induction with
additional IT therapy on days 8 and 15 if CNS leukemia (CNS 2 or CNS 3) is present at
diagnosis. If required, for patients with CNS 2 and 3 at diagnosis, IT therapy will continue
until 2 consecutive CSF studies are normal (i.e., days 29 and 36).
Consolidation:
HDMTX 2 mg/m2 IV day 43 and 50
6 MP 75 mg/m2 PO days 43-56
Continuation Therapy (120 weeks):
Week:
1. Dex + VCR
2. VP-16 + CTX
3. 6-MP + MTX
4. MTX + Ara-C
5. Dex + VCR
6. VP-16 + CTX
7. 6-MP + HDMTX
8. 6-MP + MTX
9. Dex + VCR
10. VP-16 + CTX
11. 6-MP + MTX
12. MTX + Ara-C
13. Dex + VCR
14. VP-16 + CTX
15. 6-MP + HDMTX
These sequences will be repeated through week 52, after which 6MP/MTX will be given weekly
to complete 120 weeks.
IT MHA (MTX, hydrocortisone, Ara-C) on weeks 1, 2, 7, and 15 and then every 4-8 weeks
depending on CNS status and risk status.
Dosages, Schedules and Routes:
VP 16 225 mg/m2 IV once a week
Cyclophosphamide 300 mg/m2 IV (with MESNA) once a week in addition to the 6 hour IV
hydration
6-MP 75 mg/m2 PO; daily x 7
MTX 40 mg/m2 IM or IV once a week
Ara-C 300 mg/m2 IV push; once a week
Dex 8 mg/m2/day PO; in 3 divided doses daily x 7
VCR 1.5 mg/m2 IV push (max. 2.0 mg)
HDMTX 2 g/m2 IV over 2 hours; every 8 weeks x 7
- B-Cell Non-Hodgkins Lymphoma
Overview - the chemotherapy regimen used varies with grouping based on extent of disease
Group A
Induction (COPAD x 2 cycles):
Cyclophosphamide 500 mg/m2/day (divided every 12 hour) IV (with MESNA) Day 1, 2, 3
Vincristine 2.0 mg/m2 IV Day 1
Vinblastine 6 mg/m2 IV Day 6
Prednisone 60 mg/m2/day (bid) PO Day 1-5
Adriamycin 50 mg/m2 (over 6 hrs) IV Day 1
G-CSF 5 mcg/kg/day until count recovery.
Group B
COP Induction:
Cyclophosphamide 300 mg/m2 IV (divided every 12 hours) IV (with MESNA) Day 1
Vincristine 1.0 mg/m2 IV Day 1
Prednisone 60 mg/m2/day (divided bid) PO days 1-7
CNS Therapy Intrathecal Day 1 - dose age adjusted
COPAD-M3 Induction x 2 cycles:
Vinblastine 6 mg/m2 IV Day 1
HD MTX 3 mg/m2 IV over 3 hours Day 1 with leucovorin rescue
CNS Therapy intrathecal each age adjusted Day 2, 6
Cyclophosphamide 500 mg/m2/day (second course 1 mg/m2/day) IV (with MESNA) Day 2, 3, 4
Adriamycin 50 mg/m2 IV Day 2
Prednisone 60 mg/m2 (divided bid) PO Day 1-5
G-CSF 5 mcg/kg/day until count recovery
CYM Consolidation x 2 cycles:
HD MTX 3 mg/m2 IV over 3 hours Day 1 with leucovorin rescue
Ara-C 100 mg/m2/day CI/IV (x 5 days) Day 2-6
CNS Therapy intrathecal each age adjusted Day 2 and 7
Maintenance:
Prednisone 60 mg/m2/day (divided bid) PO Day 1-5
HDMTX 3 mg/m2 IV over 3 hours Day 1 with leucovorin rescue
CNS Therapy intrathecal each age adjusted Day 2
Cyclophosphamide 500 mg/m2/day IV (with MESNA) Day 2, 3
Adriamycin 50 mg/m2 IV Day 3
Vincristine 2 mg/m2 IV Day 1
G-CSF 5 mcg/kg/day until count recovery
- Limited Stage Non-Hodgkins Lymphoma
Induction:
Vincristine 2 mg/m2 IV days 1, 22 (maximum dose 2 mg)
Vinblastine 6 mg/m2 IV, day 8
Prednisone 40 mg/m2/day in 3 divided doses x 28 days
Adriamycin 30 mg/m2/day IV over one hour days 1 and 22
Cyclophosphamide 750 mg/m2/day IV days 1 and 22
Triple IT chemotherapy for participants with head and neck primary tumors on days 1, 8, 22.
Each dose age adjusted.
Consolidation - start day 43:
Adriamycin 30 mg/m2 by IV
Cyclophosphamide 750 mg/m2
Prednisone 40 mg/m2 in 3 divided doses x 5 days
Vincristine 2.0 mg/m2 (max. 2.0 mg) by IV
Triple IT chemotherapy for head and neck primaries on days 43 and 64.
Maintenance:
Maintenance chemotherapy will be administered only to patients with lymphoblastic lymphoma
and will consist of 24 weeks of chemotherapy with oral daily 6-MP and weekly oral
methotrexate (and TIT every 6 weeks for patients with head and neck primaries) after
induction/consolidation.
- Hodgkins Disease
Participants with favorable disease will receive VAMP chemotherapy:
VAMP chemotherapy doses and schedule:
Vinblastine 6 mg/m2, IV day 1, 15 (maximum dosage: 10 mg)
Adriamycin 25 mg/m2, IV day 1, 15
Methotrexate 20 mg/m2, IV day 1, 15
Prednisone 40 mg/m2 PO day 1-14 divided into 3 daily doses
Repeat cycle every 28 days, total number of cycles = 6 (NO RADIATION THERAPY)
Participants with unfavorable disease will receive VAMP and COP:
VAMP chemotherapy doses (cycles 1, 3, 5, 7)
Vinblastine 6 mg/m2 IV day 1, 15
Adriamycin 25 mg/m2 IV day 1,15
Methotrexate 20 mg/m2 IV day 1, 15
Prednisone 40 mg/m2 (divided into 3 daily doses) PO day 1-14
COP chemotherapy doses (cycles 2, 4, 6, 8)
Cyclophosphamide 600 mg/m2 IV (with MESNA) day 1, 8
Vincristine 1.4 mg/m2 IV day 1,8 (max dose 2 mg)
Procarbazine 100 mg/m2 PO day 1-14
(NO RADIATION THERAPY)
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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