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Airway Microbiota Based Treatment of Asthma in Preschool Children — AMBT  

Asthma in Children Clinical Trial

Official title:
Effects of Airway Microbiota and Blood Eosinophils Based Therapy or Treatment Using Current Clinical Guidelines in Recurrent Preschool Wheeze

Clinical Trial Summary

Airway microbiota pattern may related the preschool asthma exacerbation. This is a single-center, randomized-controlled trial, the study will compare the management of preschool wheeze determined by airway microbiota phenotype and blood eosinophils level to the management using current clinical guidelines.

Clinical Trial Description

In this study, participants will be children aged 1-5 years who have recurrent wheezing and will be allocated to one of two treatment groups, either current clinical care or airway microbiota and blood eosinophils phenotype based management for 3 months.They will be followed up for one year after the intervention. The primary outcome is the frequency of unscheduled healthcare visit for wheezing, the secondary outcome parameters are events of severe wheezing requiring oral or intravenous steroids, events of emergency department visit and hospital admissions, the changes of Test for Respiratory and Asthma Control in Kids (TRACK) score and Paediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) score. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04527016
Study type Interventional
Source Children's Hospital of Fudan University
Contact Yuanyuan Qi
Phone 86-021-64931129
Email qiyuanyuan3636@hotmail.com
Status Recruiting
Phase Phase 4
Start date October 18, 2021
Completion date December 2023
View Details
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