Asthma in Children Clinical Trial
Official title:
Norwegian Mother and Child Study - Causal Pathways for Asthma (CASPAR)
The objective of this study is to investigate if maternal intake of vitamins A and D from food and dietary supplements during pregnancy, and infant supplementation with these vitamins, are associated with development of asthma in the offspring.
This study was conducted as part of the research project "Causal pathways for asthma" funded
by the Norwegian Research Council (2013-2017). The overall objective was to study if
different pregnancy and early life exposures affect the risk of asthma and allergic diseases
in children, and if these exposures exert their effects through epigenetic mechanisms, more
specifically DNA methylation.
For this project, including the current study, existing data from the Norwegian Mother and
Child Study (MoBa file version 9, 115 398 children and 95 248 mothers) were linked with the
Medical Birth Registry of Norway and the Norwegian Prescription Database. The MoBa study
recruited pregnant women between 1999 and 2008, at approximately 18 weeks of gestation.
Beginning 2002, women completed a food frequency questionnaire about dietary intake (food
and supplements) in pregnancy. A panel of maternal plasma biomarkers, including plasma
retinol and 25-hydroxyvitamin D2 and D3, was available for a random sample of around 3,000
women who gave birth in 2002 and 2003.
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