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NCT03099902 Clinical Trial

Secondhand Smoking in Asthmatic Children

Asthma in Children Clinical Trial

Official title:
Association Between Maternal Smoking and GSTP1 and TNFa Polymorphism in Children With Asthma/Wheezing

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03099902
Other study ID # 14/1-3-2011
Secondary ID
Status Completed
Phase N/A
First received March 22, 2017
Last updated April 10, 2017
Start date November 1, 2010
Est. completion date September 1, 2015

Study information
Verified date April 2017
Source AHEPA University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.

Recruitment information / eligibility
Status Completed
Enrollment 90
Est. completion date September 1, 2015
Est. primary completion date September 1, 2015
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 12 Months to 18 Years
Eligibility Inclusion Criteria:

- Subjects 1-18 years old with doctor diagnosed asthma/wheezing

Exclusion Criteria:

- Premature birth (< 36 gestation weeks)

- Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Lung function
Spirometry test
• White blood cell DNA extraction
GSTP1 and TNFa polymorphisms with PCR
• Urinary testing
Urinary nicotine and cotinine detection

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
AHEPA University Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary GSTP1 and TNFa variants in children with asthma 0 days
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