Asthma Copd Clinical Trial
— PIMABODOfficial title:
Phenotype Identification Based on Multimodal MRI Analysis of Patients With Bronchial Obstructive Diseases
Verified date | February 2024 |
Source | University Hospital, Bordeaux |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The hypothesis is that pulmonary and cardiac proton MRI allows phenotyping of patients with bronchial obstruction by cluster analysis based on quantitative multimodal imaging of bronchi, pulmonary vessels, pulmonary parenchyma, right and left ventricular function, myocardial fibrosis and pulmonary arterial pressure. Such imaging will also offer the advantage of being non-irradiating and without contrast products, which will ultimately allow CT to be replaced by MRI in the follow-up of bronchial obstructive patients, thus avoiding the risks associated with repeated exposure to ionizing radiation.
Status | Active, not recruiting |
Enrollment | 100 |
Est. completion date | March 30, 2024 |
Est. primary completion date | March 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 40 Years to 70 Years |
Eligibility | Inclusion Criteria: - Man or woman aged between 40 and 70 years. - Having benefited under the current care of spirometry showing FEV / FVC pre-bronchodilation <0.70 at steady state (i.e., without exacerbation from at least 4 weeks). - Having a diagnosis of asthma according to GINA 2019 without smoking restrictions or COPD according to GOLD 2019 but unrestricted to any level of bronchial reversibility to bronchodilator established by the pulmonologist. - On stable cardiopulmonary medications for at least 4 weeks - Having given his written informed consent. Exclusion Criteria: - Subject deprived of liberty by judicial or administrative decision. - Major protected by law. - Subject not affiliated to a social security scheme, whether or not the beneficiary of such a regime. - Pregnant or breastfeeding women - Inability to complete the Questionnaire SF-36 and SGQLQ. - Subject in times of exclusion in relation to another protocol. - History of pulmonary fibrosis, primary pulmonary hypertension and cystic fibrosis. - History of lung resection (referred to oncological or volume reduction) - History of cancer except skin cancer (squamous and Basal) under 5 years - History of chest radiation - Pacemaker carrier subject or implantable defibrillator, intraocular metallic foreign body, metal clip intracranial, heart valve prosthesis kind Starr-Edwards pre-6000, or biomedical insulin pump type device, Neurostimulator or cochlear implant, Metal patches. - Subject claustrophobic or unable to stay elongate during 30 minutes. - Subject with a waist circumference greater than 200 cm. - Occurrence of an exacerbation between the FE and MRI - Uninterpretable MRI |
Country | Name | City | State |
---|---|---|---|
France | Centre hospitalier de la Côte Basque | Bayonne | |
France | Clinique Saint Augustin | Bordeaux | |
France | Centre Médical Toki Eder | Cambo-les-Bains | |
France | Hôpital Le Cluzeau - CHU de Limoges | Limoges | |
France | Centre de Pneumologie Bordeaux Rive droite | Lormont | |
France | Hôpital Haut-Lévêque - CHU de Bordeaux | Pessac |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Bordeaux |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Determine the number of the clusters | Number of the clusters will be defined using principal component analysis and dendrogram, based on the multimodal lung and heart MRI analysis | Day 30 | |
Primary | Determine the Quality of the clusters | Quality of the clusters will be defined using Dunn index and non-hierarchical analysis based on the multimodal lung and heart MRI analysis | Day 30 | |
Secondary | Assessment of age | Day 1 | ||
Secondary | Assessment of sexe | Day 1 | ||
Secondary | Assessment of tobacco consumption | Day 1 | ||
Secondary | Assessment of disease duration | Day 1 | ||
Secondary | Evaluation score of SF-36 questionnaire | Determine the quality of life. SF36: 36-Item Short Form health survey Minimum = 0 and maximum = 100 Higher score means better outcome | Day 1 | |
Secondary | Evaluation with St Georges Quality of Life Questionnaire | Determine the quality of life. Minimum = 0 and maximum = 100 Higher score means worse outcome | Day 30 | |
Secondary | Evaluation of comorbidities | The presence of various comorbidities will be checked in a yes/No manner :
rhinitis sinusitis nasal polyposis gastroesophageal reflux obstructive sleep apnea depression anxiety allery heart failure (Left or Right) hypertension myocardial infarction stroke arteriopathy arythmia diabetis dyslipidaemia obesity denutrition osteoporosis |
Day 1 | |
Secondary | Determine of Forced Expiratory Volume in one sec (FEV-1) during spirometry before and after bronchodilator | Assessment of FEV-1/FVC during spirometry before and after bronchodilator | day 1 | |
Secondary | Determine of Forced Vital Capacity (FVC) during spirometry before and after bronchodilator | Assessment of FEV-1/FVC during spirometry before and after bronchodilator | day 1 | |
Secondary | Determine of slow Vital Capacity (VC) during spirometry before and after bronchodilator | day 1 | ||
Secondary | Determine of Total Lung Capacity (TLC) during spirometry before and after bronchodilator | day 1 | ||
Secondary | Determine of Functional Residual Capacity (FRC) during spirometry before and after bronchodilator | day 1 | ||
Secondary | Determine of Residual Volume (RV) during spirometry before and after bronchodilator | day 1 | ||
Secondary | Determine of Carbon monoxide transfer capacity (TLCO) | day 1 | ||
Secondary | Determine the value of blood heamoglobin | day 1 | ||
Secondary | Determine the value of blood eosinophils | day 1 | ||
Secondary | Determine the value of blood C-reactive protein | day 1 | ||
Secondary | Determine the value of blood B-type natriuretic peptide | day 1 | ||
Secondary | Determine the value of blood total IgE at | day 1 | ||
Secondary | Determine the value of blood total IgE | day 1 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT06099145 -
Clinical and Medico-economic Validation of the HEPHAI Solution.
|
N/A | |
Completed |
NCT06417931 -
Medication Adherence and Use of Inhaler Devices in Patients With Asthma or COPD
|
N/A | |
Completed |
NCT05764343 -
The Effect of Immediate Smoking Cessation Interventions for Smokers With Chronic Airway Diseases
|
N/A | |
Recruiting |
NCT06039943 -
Relationship Between Acoustic Breath Sounds and Spirometry
|
N/A | |
Active, not recruiting |
NCT05006521 -
Single and Multiple Ascending Dose Study of KN-002
|
Phase 1 | |
Recruiting |
NCT05299385 -
The Study for Evaluating the Clinical Effectiveness and Safety of Respiratory Rehabilitation Software 'Redpill Breath'(COPD, Asthma, Lung Cancer, Etc.)
|
Phase 3 | |
Recruiting |
NCT04233190 -
A Multicenter, Randomized, Parallel, Two-Period, Non-Inferiority Study of EurofarmavsAlenia in Asthma and COPD Treatment
|
Phase 3 |