Challenge Test for Acetylsalicylic Acid Hypersensitivity

Asthma, Aspirin-Induced Clinical Trial

Official title: Challenge Test for Acetylsalicylic Acid Hypersensitivity

Status Not yet recruiting

Clinical Trial Summary

The investigators want to find new challenge test for Acetylsalicylic hypersensitivity / Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient as the already established protocols in terms of sensitivity and specificity.

Clinical Trial Description

Hypersensitivity to Acetylsalicylic Acid or Aspirin (and other NSAIDS) is a condition that affects up to 2,5% of the population. Most cases are seen in a complex of such hypersensitivity with chronic eosinophilic rhinosinusitis with nasal polyposis and asthma. Despite research in finding a reliable in-vitro-test for the condition, challenge tests are still considered gold standard. So far oral, nasal, inhalation and intravenous routes of administration has been described in literature. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• ASA Intolerant Asthma
• Asthma
• Asthma Aspirin-sensitive
• Asthma, Aspirin-Induced
• Asthma, Nasal Polyps, and Aspirin Intolerance
• Hypersensitivity
• Nasal Polyps

• NCT number: NCT01681615
• Study type: Interventional
• Source: Helse Stavanger HF
• Contact: Gregor Bachmann-Harlidstad, MD, PhD
• Phone: 0047 02900 (central)
• Email: Gregor.Bachmann-Harlidstad2@ahus.no
• Status: Not yet recruiting
• Phase: N/A
• Start date: September 2012
• Completion date: December 2013