Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Asthma Acute Clinical Trial

Official title:

Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT06171932
• Other study ID #: Zia ud din university karachi
• Status: Enrolling by invitation
• Start date: November 26, 2023
• Est. completion date: August 8, 2024

Study information

• Verified date: December 2023
• Source: University of Karachi
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

COMPARISON OF EFFICACY OF HYDROCORTISONE AND METHYLPREDNISOLONE IN ACUTE SEVERE ASTHMA

In this study Investigator will compare the efficacy of hydrocortisone and methyl prednisolone in acute severe asthma that will lead to final result and beneficial effects that will help in early resoloution of symptoms and help in preventing recurrence

Description:

investigator will compare the efficacy of hydrocortisone v/s methylprednisolone in management of patients presented with acute severe asthma in emergency.

A local study was conducted in 2009, after that there is a big research gap exists at national level although international literature is available on the same but it can not be generalized to our population due to socio, geographic and economic differences so there is dire need to conduct this study this gives a strong rationale to implement in our settings

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 60
• Est. completion date: August 8, 2024
• Est. primary completion date: August 1, 2024
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Either Gender (18 to 50 years old)

• Patient presenting to emergency department with acute severe asthma

Exclusion Criteria:

• Patients with critical illness or pregnant females. .Patient treated other than hydrocortisone and methylprednisolone. .Patients not willing to participate in study.

• Life threatening asthma

• Near fatal asthm

Related Conditions & MeSH terms

• Asthma
• Asthma Acute
• Status Asthmaticus

Intervention

Drug:
• Methylprednisolone,
No intervention required

Locations

Country	Name	City	State
Pakistan	Zia ud din hospital university	Karachi	Sindh
Pakistan	Zia ud din university	Karachi	Sindh
Pakistan	Zia ud din university hospital	Karachi	Sindh
Pakistan	Zia ud din university hospitals	Karachi	Sindh

Sponsors (1)

Lead Sponsor	Collaborator
University of Karachi

Country where clinical trial is conducted

Pakistan, 

References & Publications (1)

Aggarwal P, Bhoi S. Comparing the efficacy and safety of two regimens of sequential systemic corticosteroids in the treatment of acute exacerbation of bronchial asthma. J Emerg Trauma Shock. 2010 Jul;3(3):231-7. doi: 10.4103/0974-2700.66522. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Spirometry	Above will be check on arrival of patient to Emergency and post Managment	24 hours
Primary	Blood pressures	Vital signs at initial presentation and post managment will be recorded Blood pressure in mm HG will be recorded	24 hours
Primary	Respiratory rate	Respiratory rate at arrival and post managment will be considered Respiratory rate in Breaths/min	24 hours
Primary	Heart rate	Heart rate beats/min will be checked	24 hours
Primary	PEAK EXPIRATORY FLOW RATE	it wil be checked on arrival and post managment in Peak Expiratory Flow rate (force expiratory volume in 1 second and force vital capacity )will be examined	24 hours

External Links

•   Comparision