Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers

Asthenozoospermia Clinical Trial

Official title:

Study of the Effect of Oral Zinc Supplementation on Superoxide Radical Scavengers in Spermatozoa of Patients With Asthenospermia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02217189
• Other study ID #: Babil-3
• Status: Completed
• Phase: Phase 2
• First received: August 6, 2014
• Last updated: February 1, 2017
• Start date: July 2011
• Est. completion date: July 2012

Study information

• Verified date: February 2017
• Source: Babylon University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although several studies have considered the relationship between infertility and semen super oxide radical scavengers levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on superoxide radical scavengers activity which are important in fertility of the individual has been reported.

Description:

The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with superoxide radical scavengers activity in the seminal plasma of asthenospermic patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: July 2012
• Est. primary completion date: June 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 26 Years to 36 Years

Eligibility

Inclusion Criteria:

• the presence of asthenozoospermia in the semen sample.

Exclusion Criteria:

• the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.

Related Conditions & MeSH terms

• Asthenozoospermia

Intervention

Dietary Supplement:
• zinc sulfate
The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Locations

Country	Name	City	State
Iraq	Babylon University	Hilla	Babylon

Sponsors (2)

Lead Sponsor	Collaborator
Babylon University	Ministry of Health, Iraq

Country where clinical trial is conducted

Iraq, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Oxido-sensitive index level in spermatozoa and seminal plasma.		up to three months.
Secondary	Volume of semen.		up to three months.
Secondary	Xanthine oxidase activity in spermatozoa and seminal plasma.		up to three months.
Secondary	Catalase like activity in spermatozoa and seminal plasma.		up to three months.
Secondary	Superoxide dismutase activity in spermatozoa and seminal plasma.		up to three months.
Secondary	Progressive sperm motility percentage.		up to three months
Secondary	Total normal sperm count.		up to three months.