Double Stimulation in Women With Low Prognosis in ART

Assisted Reproductive Techniques Clinical Trial

Official title: Impact of Double Stimulation (DuoStim) in Women Affected by Low Prognosis to Assisted Reproductive Technologies

Status Recruiting

Clinical Trial Summary

The main objective of this study is to compare the cumulative ongoing pregnancy rates of two different IVF protocols in women candidate for ART characterized by low prognosis.

Clinical Trial Description

The patients will be allocated into two groups: control and study group _ In study group, patients will be treated by DuoStim protocol: The first phase of ovarian stimulation is started on the second day or third day of period. GnRH agonist will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. Five days later after oocyte retrieval, the second stimulation will be started. All embryos will be cryopreserved.

_ In control group, patients will be treated with antagonist protocol: The cycle of ovarian stimulation is started on the second day or third day of period. hCG will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. If serum progesterone on the day of trigger ≥ 1.5 ng/ml, all embryos will be cryostored; otherwise, fresh embryos will be transferred. ;

Related Conditions & MeSH terms

• Assisted Reproductive Techniques

• NCT number: NCT04531644
• Study type: Interventional
• Source: Tu Du Hospital
• Contact: Chau TM Le, PhD
• Phone: +84908429006
• Email: dr.lethiminhchau@gmail.com
• Status: Recruiting
• Phase: N/A
• Start date: May 14, 2020
• Completion date: March 30, 2024