Assisted Reproduction Clinical Trial
Official title:
Effect of Trophectoderm Biopsy for Sex Selection on the Pregnancy and Miscarriage Rates of Women Undergoing IVF/ICSI
Records of women who had trophectoderm biopsy for sex selection over the last 3 years will be reviewed and its outcome will be compared to other records of women who had IVF/ICSI without embryo biopsy.
Records of women who had trophectoderm biopsy for sex selection over the last 3 years will
be reviewed. Women will be divided into 3 groups: group 1 will comprise fertile women who
had embryo biopsy for sex selection/family balancing, group 2 will comprise infertile women
who had trophectoderm biopsy and group 3 will comprise infertile women who had IVF/ICSI
without embryo biopsy.
The pregnancy and miscarriage rates of the groups will be compared. Before starting the
embryo biopsy process couples were seen by a geneticist to assess the feasibility of the
procedure for each couple. Couples were then counselled by a gynaecologist specialised in
IVF to assess their fertility status and explain the whole procedure including the expected
success rates and risks of IVF.
Women had standard pituitary down-regulation with GnRHa (Triptorelin 0.1mg, Decapeptyl®
Ferring, Germany) day 7 after ovulation of previous cycle or on day 21 of the oral
contraceptive cycles. GnRHa was continued for 2 weeks. Human menopausal gonadotrophin(HMG)
(Merional ®IBSA) 150-300 IU/day was administered until the day of HCG administration,
Transvaginal oocyte retrieval will be performed 34-36 h after the administration of HCG.
Day 5 embryos were incubated in calcium/Magnesium free culture. A laser beam was used to
produce a hole in the zona pellucida. Trophectoderm cells were collected by gentle suction
using the biopsy pipette.
Florescent in situ hybridization of the trophectoderm nuclei with probes specific to the X-
and Y-chromosomes was performed. the embryos were frozen and the cycles deferred.The embryos
were thawed in the following cycle and if possible 2 embryos of the desired sex were
transferred.
;
Observational Model: Case Control, Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05783349 -
Predictive Value of Th1, Th2 and Th17 Cytokines on the Success of Embryo Implantation (ImmuNoFertilité)
|
N/A | |
| Completed |
NCT02154958 -
Role of Follicular Output Rate in the Prediction of in Vitro Fertilization and Intracytoplasmic Sperm Injection in Women With Unexplained Infertility
|
N/A | |
| Not yet recruiting |
NCT05356429 -
Small Molecule LCDM and GV Oocyte
|
||
| Recruiting |
NCT03904355 -
Effects of Intramural Fibroids on IVF Outcome
|
N/A | |
| Recruiting |
NCT06408948 -
A Study to Evaluate the Mass Balance of [14C]SHR7280 in Healthy Adult Volunteers
|
Phase 1 | |
| Completed |
NCT03948022 -
Luteal Support in Frozen-Thawed Embryo Transfer Cycles
|
Phase 4 | |
| Recruiting |
NCT02158026 -
Evaluation of the Role of Follicular Sensitivity Index in the Prediction of Pregnancy in Women Undergoing ICSI/IVF Without Polycystic Ovarian Syndrome
|
N/A | |
| Completed |
NCT02784457 -
Gonadotropin Releasing Hormone Antagonist in Treatment of Early-onset Severe Ovarian Hyperstimulation Syndrome
|
Phase 2 | |
| Recruiting |
NCT04426942 -
Sexuality in Medically Assisted Procreation Pregnancies
|
||
| Completed |
NCT04008966 -
Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles
|
Phase 4 | |
| Completed |
NCT03820167 -
Mitochondrial DNA in Fresh Versus Frozen Embryo Culture Media of PCOS Women Undergoing In Vitro Fertilization
|
||
| Completed |
NCT04556630 -
Experience of Lock Down Related to the Covid-19 Epidemic and Its Impact on the Project of Parenthood
|