Aspirin Resistance Clinical Trial
Official title:
Cardiovascular Events at One Year of Patients Hospitalized for Critical Limb Ischaemia and Aspirin Resistant Using the VerifyNow®. Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia
Acetylsalicylic acid (Aspirin, ASA) is the most widely prescribed drug used in primary and
secondary prevention of cardiovascular disease. However, aspirin resistance has been
described, mostly in cardiac patients and is an independent predictive factor for a poor
survival. Two frequent conditions in patients with cardiovascular diseases, diabetes and
hypercholesterolemia, are also considered as risk factors for aspirin resistance. Among
patients with peripheral arterial disease, those with critical limb ischemia have the worst
cardiovascular prognosis. At one year, 23% are dead, 25% have a major cardiovascular event
and 25% have a major amputation (which can be combined). Aspirin resistance is poorly studied
in these patients, and to our knowledge no study has been made to assess the prognosis value
of aspirin resistance on cardiovascular outcomes in critical limb ischaemia patients.
Hospitalized critical limb ischaemia patients will be tested for aspirin resistance using the
bed-side point of care VerifyNow®, and will be followed during one year, including death,
fatal and non-fatal acute coronary syndromes, cardiac decompensation, stroke, and major
amputation.
n/a
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