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Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation — APAPI  

Aspiration Pneumonia Clinical Trial

Official title:
Impact of a Strategy Based on the Unyvero® Testing System on Appropriate Antimicrobial Treatment in Patients With Suspected Aspiration Pneumonia Requiring Mechanical Ventilation : a Randomized Controlled Unblinded Trial

Clinical Trial Summary

The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms. In the absence of a reliable clinical or biological marker to differentiate between these two conditions, most patients with suspected aspiration are treated empirically with antibiotics. De-escalation of initial antibiotic treatment is encouraged based on the results of microbiological results, usually performed before starting antimicrobial treatment. However, in most hospitals, 48-72h are required to obtain the results of microbiological cultures, and to de-escalate empirical large spectrum antibiotic treatment. The use of the Unyvero®, a multiplex PCR-based testing system, for detection of respiratory bacterial pathogens would allow decreasing the percentage of patients with aspiration syndrome who will receive unappropriated antibiotic treatment at Day 3.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03763799
Study type Interventional
Source University Hospital, Lille
Contact Saadalla NSEIR, MD,PhD
Phone 03 20 44 44 95
Email Saadalla.NSEIR@chru-lille.fr
Status Recruiting
Phase N/A
Start date September 20, 2019
Completion date March 2025
View Details
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