Ascites Clinical Trial
Official title:
Comparison of Efficacy of 2 Gram Versus 4 Gram Sodium Restriction in the Management of Cirrhotic Ascites
To determine the relationship between degree of sodium restriction and dietary compliance
with clinical outcome of diuresis of portal hypertensive ascites in cirrhotic patients from
a county hospital population.
Primary objective: Demonstrate that, when accompanied by the appropriate diuretic regimen, a
No Added Salt diet (4 grams sodium per day) is as effective as a Low Sodium diet (2 grams
sodium per day) in the management of cirrhotic ascites.
Secondary objectives:
1. Demonstrate that patient acceptance is greater and diuresis faster with a No Added Salt
diet compared with a Low Sodium diet
2. Demonstrate that side-effects of diuretic therapy are the same or less when patients
are on a No Added Salt diet
3. Determine if glomerular filtration rate estimated from the modified diet in renal
disease equation differs from that obtained by a 24 hour urinary creatinine in patients
with cirrhotic ascites
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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