Infections Clinical Trial
Official title:
The Interaction of the S100A8/A9 Protein With the Innate Immune System in the Immunopathology of Acute and Chronic Liver Disease
This observational study evaluates the concentration of immune protein S100A8/A9 in different liver failure syndromes, its interaction with the immune system and validity as an immunotherapeutic target to improve survival in patients with advanced cirrhosis and/or acute on chronic liver failure.
A paradox exists in chronic liver disease whereby there is a general recognition that chronic inflammation is part of the pathophysiology, heightened when there is an acute deterioration and organ failure (acute-on-chronic liver failure), yet there is an increased susceptibility to infection due to a dysfunctional immune system, which is often the trigger for organ failure and the reason for death in these patients. A danger signal reported in other inflammatory conditions called S100A8/A9 (calprotectin) is known to activate the immune system by production of pro-inflammatory cytokines but has also been observed to promote the development immunosuppressive signals (e.g. IL-10 and MDSCs). In an attempt to explain this paradox in liver disease, this study proposes to identify at the cellular and molecular level, the triggers for S100A8/A9 production, how it varies with time in stable patients and those that have acute deteriorations including the development of organ failure, and its interaction with innate immune cells in the circulation and at tissue level. By studying this, the Investigators hope to be able to identify immunotherapeutic targets and understand whether potential immunotherapy could be applied locally or systemically. The Investigators' observations in this study could provide the basis for the future development of clinical immunomodulating agents, which may ameliorate immunopathology, reduce susceptibility to infection and could reduce mortality in critically ill patients with liver disease. Findings in this study may also have more generalizable impact especially with the recent recognition in the COVID-19 pandemic that immunomodulatory therapies may improve the clinical outcomes of inflammatory phenotypes in virus-induced severe sepsis. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06055777 -
Study of the Safety, Tolerability, and PK of SZEY-2108 Administered Intravenously to HVs in SAD and MAD Cohorts
|
Phase 1 | |
| Active, not recruiting |
NCT05963269 -
The Effect of the Game on Students' Intramuscular Injection Skills
|
N/A | |
| Not yet recruiting |
NCT02222779 -
Quantification of Transition Metals
|
N/A | |
| Completed |
NCT01976234 -
Stored RBC Transfusion and Immonomodulation
|
N/A | |
| Completed |
NCT01530763 -
Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)
|
Phase 2/Phase 3 | |
| Completed |
NCT02345135 -
Susceptibility to Infections in Ataxia Telangiectasia
|
N/A | |
| Completed |
NCT01158560 -
A Trial of Vitamin D and Health Advice for the Prevention of Upper Respiratory Tract Infections
|
Phase 3 | |
| Completed |
NCT01176786 -
Reusable Versus Disposable Draping System in Breast Reconstruction Surgery
|
N/A | |
| Active, not recruiting |
NCT05284097 -
Ad26.ZEBOV, MVA-BN-Filo Vaccination in Children and Adults Previously Vaccinated With Control in the EBOVAC-Salone Study
|
Phase 2 | |
| Enrolling by invitation |
NCT06055712 -
Antibiotic Prophylaxis in Pediatric Open Fractures
|
Phase 4 | |
| Not yet recruiting |
NCT06338345 -
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
|
N/A | |
| Recruiting |
NCT06002685 -
Partners in Children's Health (CSN): A Randomized Trial of an Attachment Based Intervention
|
N/A | |
| Completed |
NCT02802059 -
E. Coli Nissle 1917 - Suspension for Infection Prophylaxis
|
Phase 3 | |
| Completed |
NCT05289674 -
The Effect of Lactoferrin in High Calorie Formula on IL-6 and IL10 in Children With Failure to Thrive and Infection
|
N/A | |
| Recruiting |
NCT05770765 -
Creation of a Bank of Biological Materials and Associated Data Related to Patients With Infectious and Tropical Diseases
|
||
| Completed |
NCT05389540 -
Rural South and Southeast Asia Household Health Survey
|
||
| Completed |
NCT05080920 -
Rosmalip® for Cancer Infections Prevention
|
N/A | |
| Recruiting |
NCT05287438 -
Next Generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Implants: Impact of Culture Identification on Outcomes
|
N/A | |
| Recruiting |
NCT06178822 -
Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room
|
||
| Recruiting |
NCT05610098 -
Gene Expression Profiles in Spinal Tuberculosis.
|