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Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Asthma Clinical Trial

Official title:
Developing Optimal Parameters for Hyperpolarized Noble Gas (3He and 129Xe) and Inert Fluorinated Gas Magnetic Resonance Imaging of Lung Disorders

Clinical Trial Summary

The goal of this research is to optimize the MRI system to obtain ideal lung images using Hyperpolarized (HP) Noble and Inert Fluorinated Gases as contrast agents. Lung coils tuned to the frequencies of these gases will be used. This study will take place at TBRHSC in the Cardiorespiratory Department and in the Research MRI facility.

Clinical Trial Description

MR images of the lung obtained using HP 3He, HP 129Xe, and inert fluorinated gases essentially show the distribution of the inhaled gas inside the lungs. Measurements can be performed on these images to provide additional information that can be related to pulmonary function. Participation will involve at least two study visits. During the first visit, participants will provide written, informed consent, and undergo eligibility screening. Study drug administration, use of the investigational devices, and MR imaging for this study will be performed at the 3T Research MRI at the Thunder Bay Regional Health Sciences Centre (TBRHSC). Pulmonary Function Tests (PFTs) will be performed at TBRHSC by a Registered Respiratory Therapist (RRT) and an MR Tech will be present for the duration of participant scans. Participants will be placed in the MRI with the appropriate chest coil wrapped around them like a vest. Several inhalation procedures will be carried out during scanning. Participants safety will be closely monitored throughout the entire study. ;

Study Design

Related Conditions & MeSH terms

  • Asbestosis
  • Asthma
  • Bronchiectasis
  • Chronic Obstructive Pulmonary Disease
  • Cold Virus
  • Cystic Fibrosis
  • Embolism
  • Emphysema
  • Fibrosis
  • Hypertension, Pulmonary
  • Interstitial Lung Disease
  • Lung Cancer
  • Lung Diseases
  • Lung Diseases, Interstitial
  • Lung Diseases, Obstructive
  • Lung Infection
  • Lung Resection
  • Lung Transplant
  • Mesothelioma
  • Obstructive Sleep Apnea
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Dysplasia
  • Pulmonary Embolism
  • Pulmonary Fibrosis
  • Pulmonary Hypertension
  • Seasonal Allergies
  • Sleep Apnea, Obstructive
Clinical Trial Details
NCT number NCT02748798
Study type Interventional
Source Thunder Bay Regional Health Research Institute
Contact Mitchell S Albert, PhD
Phone 807-684-7270
Email albertmi@tbh.net
Status Recruiting
Phase Early Phase 1
Start date November 10, 2020
Completion date December 22, 2023
View Details
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