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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT02280343
Other study ID # UERJ
Secondary ID
Status Recruiting
Phase N/A
First received October 24, 2014
Last updated June 30, 2015
Start date March 2013
Est. completion date March 2016

Study information

Verified date June 2015
Source Rio de Janeiro State University
Contact Paula Sá, research
Phone 552123340705
Email paulamorisco@hotmail.com
Is FDA regulated No
Health authority Brazil: National Committee of Ethics in Research
Study type Observational

Clinical Trial Summary

Inhalation of dust containing asbestos results in a process of interstitial pulmonary fibrosis called asbestosis. The Forced Oscillation Technique (FOT) evaluates the respiratory mechanics describing resistive, elastic and inertial properties. We believe that this technique may contribute to the early diagnosis of asbestosis.


Description:

The aims of this study were (1) to use the FOT to analyze how respiratory mechanics is affected in patients with asbestos exposed, (2) to identify the best FOT parameters for the diagnosis of respiratory changes in these patients (3) Assess whether the presence of obstructive changes is associated with the smoking habit.The control group (CG) included 24 subjects with normal spirometric data and without a history of smoking or pulmonary disease formed by workers and students UERJ and FioCruz. Volunteers with asbestos exposure were from the Department of CESTEH/ FioCruz, totaling 24 exposed and 7 with diagnoses of asbestosis.

The diagnosis of asbestosis was established based on a history of substantial exposure to asbestos dusts and compatible radiological features, together with exclusion of other competing diagnoses.

The tests included a standardized questionnaire on respiratory symptoms, clinical evaluation; Plain radiography of the chest; FOT, plethysmography and spirometry, in that order.


Recruitment information / eligibility

Status Recruiting
Enrollment 2
Est. completion date March 2016
Est. primary completion date March 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- diagnosis of asbestosis

Exclusion Criteria:

- other diseases

Study Design

Time Perspective: Cross-Sectional


Related Conditions & MeSH terms


Intervention

Other:
evaluated lung function
lung function tests

Locations

Country Name City State
Brazil Paula Morisco de Sá Rio de Janeiro

Sponsors (1)

Lead Sponsor Collaborator
Rio de Janeiro State University

Country where clinical trial is conducted

Brazil, 

Outcome

Type Measure Description Time frame Safety issue
Primary changes in pulmonary mechanicals 1 year No
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