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Clinical Trial Summary

- Arthroscopic shoulder surgeries in adults are accompanied with severe immediate postoperative pain reported in approximately 45% of patients. For quicker recovery and rehabilitation of these patients, postoperative analgesia is mandatory.

- Different analgesic modalities have been proposed including parenteral opioids, intra-articular injection of local anesthetics, interscalene brachial plexus block (ISB), and a suprascapular nerve block (SSNB), with varying degrees of effectiveness and multiple reported side effects.

- A recent meta-analysis demonstrates that suprascapular block results in 24-h morphine consumption and pain scores similar to ISB, so, it may be considered an effective and safe alternative for interscalene block in shoulder surgery, with less motor restriction, and fewer complications.

- Different agents are used as adjuvants to local anesthetics during peripheral nerve block to prolong its analgesic action including magnesium sulfate.

- A meta-analysis by Mengzhu et al., concluded that magnesium sulfate combined with local anesthetics in perineural nerve blocks provided better analgesic efficacy and may be a promising analgesic for perineural nerve blocks.

- Antinociceptive effects of magnesium are due to the regulation of calcium influx into the cell and a non-competitive antagonism of the NMDA receptors


Clinical Trial Description

The aim of this study is to evaluate the effects of magnesium sulfate as an adjuvant to bupivacaine in suprascapular nerve block on the duration and quality of postoperative analgesia following shoulder arthroscopy, postoperative pain VAS scores, intraoperative fentanyl requirements, sedation scores, respiratory depression, postoperative 24 hours cumulative morphine consumption. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03602469
Study type Interventional
Source Mansoura University
Contact Hanaa M Elbendary, MD
Phone 00201005781768
Email hanaa_elbendary@yahoo.com
Status Not yet recruiting
Phase N/A
Start date July 2018
Completion date January 2019

See also
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Terminated NCT02867904 - Intra-Operative Corticosteroid Injection During Arthroscopic Shoulder Surgery Phase 4
Completed NCT01351363 - Prediction Of Post Operative Pain Following Arthroscopic Shoulder Surgery N/A
Completed NCT03691922 - Erector Spinae Block Versus Shoulder Periarticular Anesthetic Infiltration for Arthroscopic Shoulder Surgery N/A
Not yet recruiting NCT03738735 - Randomized, Controlled Trial of Hyperosmotlar Saline for Rotator Cuff Repair Irrigation Solution Phase 4
Recruiting NCT05739201 - ISB, SSNB, and PENG Block for Arthroscopic Shoulder Surgery N/A
Terminated NCT04633837 - Examining the Effectiveness of a Connective Tissue Matrix Implant in Reducing Post-operative Pain and Narcotic After Outpatient Arthroscopic Shoulder Surgery N/A
Completed NCT04669639 - A Comparison of ESP Block to SSN Block for Analgesia in Shoulder Surgery N/A
Active, not recruiting NCT04675671 - Analgesic and Anxiety Efficacy of Preemptive Pregabalin
Completed NCT03277326 - Interscalene vs Anterior and Posterior Suprascapular Nerve Block for Shoulder Arthroscopic Surgeries N/A
Recruiting NCT00731146 - Effects of Technique on the Local Anesthetic Dose Required for Interscalene Brachial Plexus Block N/A
Completed NCT03212443 - Combined Suprascapular and Axillary Nerve Blocks for Arthroscopic Shoulder Surgery N/A